Volume 2 Supplement 1
Comparing intra-abdominal pressures in different body positions via a urinary catheter and nasogastric tube: a pilot study
© Rooban et al.; licensee Springer 2012
Published: 5 July 2012
Intra-abdominal pressure (IAP) is most commonly measured via the bladder with the patient in the supine position. In the ICU, patients are nursed with the head of the bed elevated at 30° (HOB30) to reduce the risk of ventilator-associated pneumonia. This study investigated whether gastric pressure at HOB30 can be used as a surrogate measure of IAP via the bladder in the supine position.
A prospective observational study was conducted in a single-centre intensive care unit. A total of 20 patients were included. IAP was recorded simultaneously via the bladder catheter (bladder pressure, IBP) and via nasogastric tube (gastric pressures, IGP) in the supine and HOB30 position. Each patient had three sets of IAP measurements performed at least 4 h apart.
In the supine position, mean IBP was 12.3 ± 4.5 mmHg compared to IGP of 11.8 ± 4.7 mmHg. The bias between the two groups was 0.5 and precision of 3.7 (LA, -6.8 to 7.5 mmHg). At 30 degrees, mean IBP was 15.8 ± 4.9 mmHg compared to IGP of 13.1 ± 6.1 mmHg. The bias between both groups was 2.7 with a precision of 5.5 (LA, -8.0 to 13.5). Comparing IBP in the supine position with IGP at 30° showed a bias of -0.8 and precision of 5.6 (LA, -10.1 to 11.6 mmHg).
IAP measured via a nasogastric tube was less influenced by changing the body position from supine to HOB30 than was bladder pressure.
Keywordsintra-abdominal hypertension intra-abdominal pressure abdominal compartment syndrome gastric pressure body position
Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are associated with increased morbidity and mortality in critically ill patients [1, 2]. As a result, evidence-based consensus definitions and recommendations for resuscitation and management of IAH and ACS have been developed [3, 4]. The general approach is based on four principles: (a) serial IAP monitoring, (b) medical management to reduce IAP, (c) goal-directed optimisation of systemic perfusion and organ function and (d) early surgical decompression for IAH/ACS refractory to these interventions. Cheatham and Safcsak showed that implementing these recommendations including serial IAP monitoring and early abdominal decompression at an IAP of 25 mmHg significantly increased patient survival to hospital discharge from 50% to 72% .
The World Society of Abdominal Compartment Syndrome (WSACS; http://www.wsacs.org) recommends the measurement of IAP via the bladder in the supine position at end-expiration, ensuring that abdominal contractions are absent and with the transducer zeroed at the level of the mid-axillary line [3, 4]. Intermittent and continuous measurement of IAP via the stomach, bladder and peritoneal cavity have been validated and used when this method is contra-indicated .
In the intensive care unit, most ventilated patients are nursed with the head of the bed elevated at 30° or 45° to reduce the risk of ventilator-associated pneumonia and gastric reflux [7, 8]. Measuring IAP in the semi-recumbent position has been shown to adversely affect IAP readings when measured via the intravesical route [9, 10]. The aim of our study was to compare the influence of body position, specifically head of bed elevation at 30° (HOB30), on bladder and gastric pressure. Furthermore, we examined the correlation between the intrabladder pressures (IBP) and intragastric pressures (IGP) in the supine and HOB30 position. Our hypothesis was that IGP at 30° are not influenced by the descent of abdominal contents in the semi-recumbent position and therefore would represent IBP in the supine position.
Materials and methods
The Human Research Ethics Committee of Fremantle Hospital approved this prospective pilot study.
Patients who were admitted to the Intensive Care Unit at Fremantle Hospital between December 2009 and April 2010 were consecutively enrolled in the trial. Patient inclusion criteria required them to be older than 18 years of age, to be sedated and mechanically ventilated and to have both a nasogastric tube and indwelling urine catheter in place. Reasons for exclusion were recent oesophageal, gastric or bladder surgery; patients who were moribund and unlikely to survive 24 h; patients who were pregnant and patients who were unable to lay flat for any reason. Patients were sedated to a Richmond Agitation and Sedation Scale of -5 (RASS) to ensure that abdominal muscle contractions were absent. Written informed consent was obtained by the next of kin as determined by the ethics committee.
Once the patient was enrolled, IBP was measured according to the WSACS consensus recommendations using the standard bladder technique . The IBP was measured through the patient's indwelling catheter, according to the modified Kron technique using an AbViser 300 or AbViser 611 kit (AbViser, Wolfe Tory Medical, Salt Lake City, UT, USA) [11, 12]. The transducer was zeroed on the mid-axillary line at the level of the superior iliac crest. After 20 ml of normal saline was injected through the indwelling urine catheter, the IAP was measured at end-expiration in millimetres of mercury. The pressure transducer was connected to the electronic monitoring equipment available in the intensive care unit.
Gastric pressures were measured via a standard nasogastric tube. Prior to measurement, the nasogastric tube was aspirated for air or gastric contents, and its position was confirmed by chest X-ray. A three-way stopcock was attached between the nasogastric tube and a standard pressure monitoring line. A Luerlok syringe was attached to one port of the stopcock for the instillation of 100 ml of sterile saline from the closed pressure monitoring system to ensure a continuous column of fluid between the stomach and the pressure transducer. A point level with the xiphisternum on the mid-axillary line was marked, and the transducer was zeroed at that level. This position corresponds to the position of the stomach allowing accurate measurement of gastric pressure in different body positions. After each measurement, the instilled volume of saline was then aspirated out of the nasogastric tube.
Each set of measurements included IBP and IGP in the supine position followed by the semi-recumbent position at HOB30. All four measurements were taken over a period of 5 to 10 min or less to reduce the possibility of changes in IAP over time. Three sets of readings were taken at least 4 h apart over a 24-h period.
Once patients were enrolled in the study, data on patient demographics including age, sex, weight, height, body mass index, diagnosis at admission, co-morbidities and presence of IAH risk factors were collected. Severity of illness for the 24-h period before the first IAP measurement was documented through calculation of the Acute Physiology and Chronic Health Evaluation score II, Simplified Acute Physiology Score II and Sequential Organ Failure Assessment Scores. For each set of IAP readings, mean arterial pressure, positive end-expiratory pressure and RASS were recorded. All study data were recorded on a case report form on paper and subsequently entered as de-identified patient data on a secure Microsoft Access database.
IAH was defined by a sustained or repeated pathological elevation in IAP ≥ 12 mmHg, whilst ACS was defined as a sustained IAP > 20 mmHg that is associated with new organ dysfunction/failure .
Statistical analysis was performed using Medcalc (Medcalc version 22.214.171.124, Mariakerke, Belgium) and PASW Statistics 18 (SPSS Inc., Chicago, IL, USA). Data are presented as proportions (with 95% confidence interval as appropriate) or mean ± standard deviation (SD). Paired Student's t tests were used to test for statistical significance between two different measures of pressure on the same patients at the same times. General linear modelling (GLM) for repeated measures was used to test whether differences between the same measures of pressure on the same patients changed significantly over time. A significant level of p < 0.05 was used throughout. For assessing agreement between two methods of measurement of IAP, we used Bland-Altman plots . The WSACS recommends a bias below 1 mmHg and a precision (defined as the standard deviation of the bias) of 2 mmHg, or thus, limits of agreement of -4 to +4 mmHg are necessary for two IAP techniques to be considered equivalent . Pearson correlation plots were also utilised to assess agreement between the two methods. The Pearson correlation (r2) is +1 in the case of a perfect positive (increasing) linear relationship, and as it approaches zero, there is less correlation.
57 ± 19
88 ± 22
171 ± 10
30 ± 7
Severity of illness scores
15 ± 7
35 ± 13
8 ± 3
Etiology of illness (%) (n)
Co-morbidities (%) (n)
Chronic renal failure
GLM for repeated measures showed that for all four measures, the IAP did not change significantly over time (Huyn-Feldt test for within-subjects effects p > 0.34; Bonferroni-corrected pairwise comparisons, p ≥ 0.50). Therefore, the results for all 60 sets of measurements were pooled.
Comparison between different pressure sites and body positions
Bias (95% CI) in mmHg
Precision (limits of agreement) in mmHg
IBP supine vs IGP supine
0.3 (-0.6 to 1.3)
3.7 (-6.8 to 7.5)
IBP HOB30 vs IGP HOB30
2.7 (1.3 to 4.1)
5.5 (-8.0 to 13.5)
IBP supine vs IGP HOB30
-0.8 (-2.2 to 0.7)
5.6 (-10.1 to 11.6)
This study found that IGP changed to a lesser degree than IBP when changing the body position from supine to HOB30. The WSACS recommends using the IBP in the supine position to indirectly measure IAP, but gastric pressures have shown to be a valid alternative in cases where the bladder is contra-indicated. Collee et al.  used a simple water column technique to measure IGP in 26 intensive care patients and found a good correlation between bladder and gastric pressures. Sugrue et al.  showed with a modified nasogastric tube (air-filled) that in nine patients undergoing laparoscopic cholecystectomy, the IGP reflected IBP accurately (mean difference of 0.35 mmHg). Turnbull et al.  also used air-filled balloon catheters and compared them with direct IAP measurement. They found an estimated 2.5-mmHg difference between both techniques which is acceptable. Semi-continuous measurement of IAP using an intra-gastric compliance catheter has shown a good correlation between gastric and direct IAP measurement with a mean difference of only 0.12 mmHg and acceptable limits of agreement . Similar results were published in vitro  and in vivo [20, 21]. However, this could not be confirmed by Davis et al.  who demonstrated in children that the bias between nasogastric and bladder pressures was 1.3 mmHg with limits of agreement of -5.42 and 2.82. Becker et al. showed that continuous IAP measurements via the CiMON catheter (Pulsion Medical Systems, Munich, Germany) in cirrhotic patients did not correlate well with direct IAP measurements (bias of 4.9 mmHg) . Finally, some animal studies have shown poor correlation between IGP and IBP .
Most patients in the ICU are nursed with the head of bed elevated at 30° to 45° to reduce the risk of ventilator-associated pneumonia [7, 8]. Studies have shown that placing these patients in the semi-recumbent position significantly increases IAP . This could lead to an over-estimation of the measured IAP.
Ideally, we need to have a method of measuring IAP in HOB30. In this study, IGP HOB30 was compared with the gold standard IAP supine via the bladder. Comparing the two methods, we found an acceptable bias, but the precision and limits of agreement exceeded the pre-defined range . Therefore, based on our results, we currently cannot recommend the use of IGP in the HOB30 to be used as an alternative to IBP in the supine position.
It is uncertain if this IBP increase between supine and HOB30 is a true pressure increase throughout the entire abdomen or represents a pressure gradient within the abdomen caused by a hydrostatic fluid column or a compression of abdominal organs with a subsequent compression on the bladder or even a localized pressure difference .
There might have been extra-abdominal body components such as the mediastinum or lungs increasing IAP, which might have affected IGP and IBP readings to different extent. If we believe that the abdomen behaves as a hydraulic system , then the IBP increase between supine and HOB30 is real and clinicians should take this into account in patients with impending ACS. Further research needs to be directed towards whether the abdomen is a truly fluid container or whether it is made up of different organs with fluid and air-filled contents exerting varying pressures on these compartments as this may help explain the significance of higher semi-recumbent measurements .
The main limitations of our trial are that it only represented a very small group of patients. Forty percent of the patients had IAH but only one patient had ACS, and we cannot be certain that with higher IAP values the correlation between IBP in the supine position and IGP in the HOB30 might have improved. Although we did pay attention to make sure that the stomach was in a period of quiescent motor activity with no evidence of the phase 2 or 3 of the migrating motor complex, this could not be excluded entirely and may have influenced the IGP readings. Gastric motor activity was recorded by Collard and Romagnoli at a rate of about three cycles per minute . Enteral feeding and ileus may also have compromised the accuracy of the IGP. However, as the IGP was lower than the IBP in the supine position, we do not think the gastric activity had a great influence on the gastric pressure. Furthermore, any residual air or residual gastric contents left in the tubing (something that is difficult to assess) might give erroneous pressure readings, hence influencing IGP. The zero reference position for measuring IGP on the mid-axillary line at the level of the xiphisternum might have influenced the readings at HOB30 when comparing with the supine position. Finally, the optimum amount of fluid to be instilled into the stomach is still unknown.
As for IBP measurements, increasing volume of fluid installed into the bladder can produce falsely elevated measurements. Therefore, the amount of 100 ml of normal saline might have been too high to adequately measure IGP. Some of these questions may be solved through bypassing the effects associated with fluid-filled systems and measuring IAP with a balloon-tipped catheter.
There are no guidelines towards critical IAP levels in patients with the HOB elevated, and it may well be that the higher readings ascertained in this position are accurate. Further research should be directed as to whether early interventions for raised IAP in the semi-recumbent position provide better outcomes in patients with ACS. Based on our results, IGP in the semi-recumbent position cannot be recommended as an estimate for IAP in supine position. Instead, IAP should be taken via an indwelling bladder catheter with the patient in a supine position to standardize values when intermittent readings are required. If readings are taken in different positions or by different routes, accuracy is reduced.
Based on our results, IGP at HOB30 position cannot be used as a surrogate measure of IBP in supine position. Although previous studies have implicated that IGP and IBP can be used interchangeably, we found large limits of agreement between the two methods. IAP measured via the nasogastric tube was less influenced by position than was the IAP measured via bladder catheter. Further research is required to assess the implication of increased IAP readings in the semi-recumbent position and whether this is due to the abdomen not being a hydraulic compartment or whether this reflects a true local increase in IAP.
abdominal compartment syndrome
general linear modelling
head of bed elevation
head of bed elevation at 30°
limits of agreement
Richmond Agitation and Sedation Scale
World Society of Abdominal Compartment Syndrome.
This article has been published as part of Annals of Intensive Care Volume 2 Supplement 1, 2012: Diagnosis and management of intra-abdominal hypertension and abdominal compartment syndrome. The full contents of the supplement are available online at http://www.annalsofintensivecare.com/supplements/2/S1.
To standardize IAP measurement technique, Wolfe-Tory provided the AbViser bladder pressure measurement kits free of charge.
- Malbrain MLNG, Chiumello D, Pelosi P, Wilmer A, Brienza N, Malcangi V, Bihari D, Innes R, Cohen J, Singer P, Japiassu A, Kurtop E, De Keulenaer BL, Daelemans R, Del Turco M, Cosimini P, Ranieri M, Jacquet L, Laterre P-F, Gattinoni L: Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 2004, 30: 822–829.PubMedView ArticleGoogle Scholar
- Malbrain MLNG, Chiumello D, Pelosi P, Bihari D, Innes R, Ranieri VM, Del Turco M, Wilmer A, Brienza N, Malcangi V, Cohen J, Japiassu A, De Keulenaer BL, Daelemans R, Jacquet L, Laterre P-F, Frank G, de Souza P, Cesana B, Gattinoni L: Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med 2005, 33: 315–322.PubMedView ArticleGoogle Scholar
- Cheatham ML, Malbrain MLNG, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppaniemi A, Olvera C, Ivatury R, D'Amours S, Wendon J, Hillman K, Wilmer A: Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations. Intensive Care Med 2007, 33: 951–962.PubMedView ArticleGoogle Scholar
- Malbrain MLNG, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppaniemi A, Olvera C, Ivatury R, D'Amours S, Wendon J, Hillman K, Johansson K, Kolkman K, Wilmer A: Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Med 2006, 32: 1722–1732.PubMedView ArticleGoogle Scholar
- Cheatham ML, Safcsak K: Is the evolving management of intra-abdominal hypertension and abdominal compartment syndrome improving survival? Crit Care Med 2010, 38: 402–407.PubMedView ArticleGoogle Scholar
- Malbrain MLNG: Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal. Intensive Care Med 2004, 30: 357–371.PubMedView ArticleGoogle Scholar
- Dodek P, Keenan S, Cook D, Heyland D, Jacka M, Hand L, Muscedere J, Foster D, Mehta N, Hall R, Brun-Buisson C: Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med 2004, 141: 305–313.PubMedView ArticleGoogle Scholar
- Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R: Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 2004, 53: 1–36.PubMedGoogle Scholar
- Cheatham ML, De Waele JJ, De Laet I, De Keulenaer B, Widder S, Kirkpatrick AW, Cresswell AB, Malbrain M, Bodnar Z, Mejia-Mantilla JH, Reis R, Parr M, Schulze R, Puig S, World Society of the Abdominal Compartment Syndrome Clinical Trials Working Group: The impact of body position on intra-abdominal pressure measurement: a multicenter analysis. Crit Care Med 2009, 37: 2187–2190.PubMedView ArticleGoogle Scholar
- De Keulenaer BL, De Waele JJ, Powell B, Malbrain MLNG: What is normal intra-abdominal pressure and how is it affected by positioning, body mass and positive end-expiratory pressure? Intensive Care Med 2009, 35: 969–976.PubMedView ArticleGoogle Scholar
- Kron IL, Harman PK, Nolan SP: The measurement of intra-abdominal pressure as a criterion for abdominal re-exploration. Ann Surg 1984, 199: 28–30.PubMed CentralPubMedView ArticleGoogle Scholar
- Malbrain ML, De laet I, Viaene D, Schoonheydt K, Dits H: In vitro validation of a novel method for continuous intra-abdominal pressure monitoring. Intensive Care Med 2008, 34: 740–745.PubMedView ArticleGoogle Scholar
- Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1: 307–310.PubMedView ArticleGoogle Scholar
- De Waele JJ, Cheatham ML, Malbrain MLNG, Kirkpatrick AW, Sugrue M, Balogh Z, Ivatury R, De Keulenaer B, Kimball EJ: Recommendations for research from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. Acta Clin Belg 2009, 64: 203–209.PubMedView ArticleGoogle Scholar
- Collee GG, Lomax DM, Ferguson C, Hanson GC: Bedside measurement of intra-abdominal pressure (IAP) via an indwelling naso-gastric tube: clinical validation of the technique. Intensive Care Med 1993, 19: 478–480.PubMedView ArticleGoogle Scholar
- Sugrue M, Buist MD, Lee A, Sanchez DJ, Hillman KM: Intra-abdominal pressure measurement using a modified nasogastric tube: description and validation of a new technique. Intensive Care Med 1994, 20: 588–590.PubMedView ArticleGoogle Scholar
- Turnbull D, Webber S, Hamnegard CH, Mills GH: Intra-abdominal pressure measurement: validation of intragastric pressure as a measure of intra-abdominal pressure. Br J Anaesth 2007, 98: 628–634.PubMedView ArticleGoogle Scholar
- De Waele JJ, Berrevoet F, Reyntjens K, Pletinckx P, De laet I, Hoste E: Semicontinuous intra-abdominal pressure measurement using an intragastric compliance catheter. Intensive Care Med 2007, 33: 1297–1300.PubMedView ArticleGoogle Scholar
- De Potter TJ, Dits H, Malbrain ML: Intra- and interobserver variability during in vitro validation of two novel methods for intra-abdominal pressure monitoring. Intensive Care Med 2005, 31: 747–751.PubMedView ArticleGoogle Scholar
- Engum SA, Kogon B, Jensen E, Isch J, Balanoff C, Grosfeld JL: Gastric tonometry and direct intraabdominal pressure monitoring in abdominal compartment syndrome. J Pediatr Surg 2002, 37: 214–218.PubMedView ArticleGoogle Scholar
- Schachtrupp A, Tons C, Fackeldey V, Hoer J, Reinges M, Schumpelick V: Evaluation of two novel methods for the direct and continuous measurement of the intra-abdominal pressure in a porcine model. Intensive Care Med 2003, 29: 1605–1608.PubMedView ArticleGoogle Scholar
- Davis PJ, Koottayi S, Taylor A, Butt WW: Comparison of indirect methods of measuring intra-abdominal pressure in children. Intensive Care Med 2005, 31: 471–475.PubMedView ArticleGoogle Scholar
- Becker V, Schmid RM, Umgelter A: Comparison of a new device for the continuous intra-gastric measurement of intra-abdominal pressure (CiMon) with direct intra-peritoneal measurements in cirrhotic patients during paracentesis. Intensive Care Med 2009, 35: 948–952.PubMedView ArticleGoogle Scholar
- Malbrain ML, De Laet IE, Willems A, Van Regenmortel N, Schoonheydt K, Dits H: Localised abdominal compartment syndrome: bladder-over-gastric pressure ratio (B/G ratio) as a clue to diagnosis. Acta Clin Belg 2010, 65: 98–106.PubMedView ArticleGoogle Scholar
- Collard JM, Romagnoli R: Human stomach has a recordable mechanical activity at a rate of about three cycles/minute. Eur J Surg 2001, 167: 188–194.PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.