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  1. Research

    Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study

    Third-generation cephalosporins (3GCs) are recommended for empirical antibiotic therapy of community-acquired pneumonia (CAP) in patients requiring ICU admission. However, their extensive use could promote the...

    Geoffroy Hariri, Jacques Tankovic, Pierre-Yves Boëlle, Vincent Dubée, Guillaume Leblanc, Claire Pichereau, Simon Bourcier, Naike Bigé, Jean-Luc Baudel, Arnaud Galbois, Hafid Ait-Oufella and Eric Maury

    Annals of Intensive Care 2017 7:35

    Published on: 24 March 2017

  2. Research

    Implementation and evaluation of a paediatric nurse-driven sedation protocol in a paediatric intensive care unit

    Optimal sedation and analgesia is a challenge in paediatric intensive care units (PICU) because of difficulties in scoring systems and specific metabolism inducing tolerance and withdrawal. Excessive sedation ...

    Lélia Dreyfus, Etienne Javouhey, Angélique Denis, Sandrine Touzet and Fabienne Bordet

    Annals of Intensive Care 2017 7:36

    Published on: 24 March 2017

  3. Research

    Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects

    Oxacillin and cloxacillin are the most frequently used penicillins for the treatment of severe methicillin-susceptible Staphylococcus aureus infections in intensive care units (ICUs), especially endocarditis. Int...

    Mathilde Neuville, Najoua El-Helali, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Alban Le Monnier, Stéphane Ruckly, Lila Bouadma, Romain Sonneville, Jean-François Timsit and Bruno Mourvillier

    Annals of Intensive Care 2017 7:34

    Published on: 22 March 2017

  4. Research

    Sepsis risk factors in infants with congenital diaphragmatic hernia

    Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia and major abdominal surgery,...

    Michaël Levy, Nolwenn Le Sache, Mostafa Mokhtari, Guy Fagherazzi, Gaelle Cuzon, Benjamin Bueno, Virginie Fouquet, Alexandra Benachi, Sergio Eleni Dit Trolli and Pierre Tissieres

    Annals of Intensive Care 2017 7:32

    Published on: 21 March 2017

  5. Research

    Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis

    The best predictors of short- and medium-term mortality of cirrhotic patients receiving intensive care support are unknown.

    Delphine Weil, Eric Levesque, Marc McPhail, Rodrigo Cavallazzi, Eleni Theocharidou, Evangelos Cholongitas, Arnaud Galbois, Heng Chih Pan, Constantine J. Karvellas, Bertrand Sauneuf, René Robert, Jérome Fichet, Gaël Piton, Thierry Thevenot, Gilles Capellier and Vincent Di Martino

    Annals of Intensive Care 2017 7:33

    Published on: 21 March 2017

  6. Research

    Acute hyperventilation increases the central venous-to-arterial PCO2 difference in stable septic shock patients

    To evaluate the effects of acute hyperventilation on the central venous-to-arterial carbon dioxide tension difference (∆PCO2) in hemodynamically stable septic shock patients.

    Jihad Mallat, Usman Mohammad, Malcolm Lemyze, Mehdi Meddour, Marie Jonard, Florent Pepy, Gaelle Gasan, Stephanie Barrailler, Johanna Temime, Nicolas Vangrunderbeeck, Laurent Tronchon and Didier Thevenin

    Annals of Intensive Care 2017 7:31

    Published on: 20 March 2017

  7. Research

    Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission

    Severely ill patients might develop an alteration of their immune system called post-aggressive immunosuppression. We sought to assess the risk of ICU-acquired infection and of mortality according to the abso...

    Christophe Adrie, Maxime Lugosi, Romain Sonneville, Bertrand Souweine, Stéphane Ruckly, Jean-Charles Cartier, Maité Garrouste-Orgeas, Carole Schwebel and Jean-François Timsit

    Annals of Intensive Care 2017 7:30

    Published on: 17 March 2017

  8. Research

    A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study

    Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. Howeve...

    Leyla Alegría, Magdalena Vera, Jorge Dreyse, Ricardo Castro, David Carpio, Carolina Henriquez, Daniela Gajardo, Sebastian Bravo, Felipe Araneda, Eduardo Kattan, Pedro Torres, Gustavo Ospina-Tascón, Jean-Louis Teboul, Jan Bakker and Glenn Hernández

    Annals of Intensive Care 2017 7:29

    Published on: 9 March 2017

  9. Research

    Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis

    Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the cl...

    Hanah Kim, Mina Hur, Hee-Won Moon, Yeo-Min Yun and Salvatore Di Somma

    Annals of Intensive Care 2017 7:27

    Published on: 7 March 2017

  10. Review

    Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review

    Intensivists’ clinical decision making pursues two main goals for patients: to decrease mortality and to improve quality of life and functional status in survivors. Patient-important outcomes are gaining wide ...

    Stéphane Gaudry, Jonathan Messika, Jean-Damien Ricard, Sylvie Guillo, Blandine Pasquet, Emeline Dubief, Tanissia Boukertouta, Didier Dreyfuss and Florence Tubach

    Annals of Intensive Care 2017 7:28

    Published on: 7 March 2017

  11. Research

    Outcomes in elderly patients admitted to the intensive care unit with solid tumors

    As the population ages and cancer therapies improve, there is an increased call for elderly cancer patients to be admitted to the intensive care unit (ICU). This study aimed to assess short-term survival and p...

    Edouard Auclin, Anaïs Charles-Nelson, Baptiste Abbar, Emmanuel Guérot, Stéphane Oudard, Caroline Hauw-Berlemont, Constance Thibault, Alexandra Monnier, Jean-Luc Diehl, Sandrine Katsahian, Jean-Yves Fagon, Julien Taieb and Nadia Aissaoui

    Annals of Intensive Care 2017 7:26

    Published on: 6 March 2017

  12. Research

    Sound level intensity severely disrupts sleep in ventilated ICU patients throughout a 24-h period: a preliminary 24-h study of sleep stages and associated sound levels

    It is well recognized that sleep is severely disturbed in patients in intensive care units (ICU) and that this can compromise their rehabilitation potential. However, it is still difficult to objectively asses...

    Maxime Elbaz, Damien Léger, Fabien Sauvet, Benoit Champigneulle, Stéphane Rio, Mélanie Strauss, Mounir Chennaoui, Christian Guilleminault and Jean Paul Mira

    Annals of Intensive Care 2017 7:25

    Published on: 3 March 2017

  13. Research

    Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study

    A common and serious complication of cardiac surgery prompting early detection and intervention is cardiac surgery-associated acute kidney injury (CSA-AKI). Urinary chitinase 3-like protein 1 (UCHI3L1) was fou...

    Jorien De Loor, Ingrid Herck, Katrien Francois, Astrid Van Wesemael, Lieve Nuytinck, Evelyne Meyer and Eric A. J. Hoste

    Annals of Intensive Care 2017 7:24

    Published on: 1 March 2017

  14. Research

    IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

    Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim o...

    Maria Angeles Jiménez-Sousa, Luz Maria Medrano, Pilar Liu, Amanda Fernández-Rodríguez, Raquel Almansa, Esther Gomez-Sanchez, Alicia Ortega, María Heredia-Rodríguez, Estefanía Gómez-Pesquera, Eduardo Tamayo and Salvador Resino

    Annals of Intensive Care 2017 7:22

    Published on: 28 February 2017

  15. Research

    Prone positioning in acute respiratory distress syndrome after abdominal surgery: a multicenter retrospective study

    The recent demonstration of prone position’s strong benefit on patient survival has rendered proning a major therapeutic intervention in severe ARDS. Uncertainties remain as to whether or not ARDS patients in...

    Stéphane Gaudry, Samuel Tuffet, Anne-Claire Lukaszewicz, Christian Laplace, Noémie Zucman, Marc Pocard, Bruno Costaglioli, Simon Msika, Jacques Duranteau, Didier Payen, Didier Dreyfuss, David Hajage and Jean-Damien Ricard

    Annals of Intensive Care 2017 7:21

    Published on: 24 February 2017

  16. Research

    Hemodynamic effects of short-term hyperoxia after coronary artery bypass grafting

    Although oxygen is generally administered in a liberal manner in the perioperative setting, the effects of oxygen administration on dynamic cardiovascular parameters, filling status and cerebral perfusion have...

    Hendrik J. F. Helmerhorst, Rob B. P. de Wilde, Dae Hyun Lee, Meindert Palmen, Jos R. C. Jansen, David J. van Westerloo and Evert de Jonge

    Annals of Intensive Care 2017 7:20

    Published on: 23 February 2017

  17. Research

    Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting

    Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality tre...

    Juan Carlos Yébenes, Juan Carlos Ruiz-Rodriguez, Ricard Ferrer, Montserrat Clèries, Anna Bosch, Carol Lorencio, Alejandro Rodriguez, Xavier Nuvials, Ignacio Martin-Loeches and Antoni Artigas

    Annals of Intensive Care 2017 7:19

    Published on: 20 February 2017

  18. Research

    Antithrombin use and 28-day in-hospital mortality among severe-burn patients: an observational nationwide study

    Previous studies have suggested that antithrombin may be beneficial for treating coagulopathy in patients with severe burns. However, robust evidence for this idea is lacking. We examined the hypothesis that a...

    Takashi Tagami, Hiroki Matsui, Yuuta Moroe, Reo Fukuda, Ami Shibata, Chie Tanaka, Kyoko Unemoto, Kiyohide Fushimi and Hideo Yasunaga

    Annals of Intensive Care 2017 7:18

    Published on: 20 February 2017

  19. Research

    Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients

    In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was associated ...

    Michael J. Lanspa, Sajid Shahul, Andrew Hersh, Emily L. Wilson, Troy D. Olsen, Eliotte L. Hirshberg, Colin K. Grissom and Samuel M. Brown

    Annals of Intensive Care 2017 7:17

    Published on: 17 February 2017

  20. Research

    Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity

    The use of novel sepsis biomarkers has increased in recent years. However, their prognostic value with respect to illness severity has not been explored. In this work, we examined the ability of mid-regional p...

    David Andaluz-Ojeda, H. Bryant Nguyen, Nicolas Meunier-Beillard, Ramón Cicuéndez, Jean-Pierre Quenot, Dolores Calvo, Auguste Dargent, Esther Zarca, Cristina Andrés, Leonor Nogales, Jose María Eiros, Eduardo Tamayo, Francisco Gandía, Jesús F. Bermejo-Martín and Pierre Emmanuel Charles

    Annals of Intensive Care 2017 7:15

    Published on: 10 February 2017

  21. Research

    Transportation of patients on extracorporeal membrane oxygenation: a tertiary medical center experience and systematic review of the literature

    Utilization of extracorporeal membrane oxygenation (ECMO) has increased worldwide, but its use remains restricted to severely ill patients, and few referral centers are properly structured to offer this suppor...

    Pedro Vitale Mendes, Cesar de Albuquerque Gallo, Bruno Adler Maccagnan Pinheiro Besen, Adriana Sayuri Hirota, Raquel de Oliveira Nardi, Edzangela Vasconcelos dos Santos, Ho Yeh Li, Daniel Joelsons, Eduardo Leite Vieira Costa, Flavia Krepel Foronda, Luciano Cesar Pontes Azevedo and Marcelo Park

    Annals of Intensive Care 2017 7:14

    Published on: 7 February 2017

  22. Research

    Relation between presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in systematic rectal swabs and respiratory tract specimens in ICU patients

    The choice of empirical antimicrobial therapy for pneumonia in intensive care unit (ICU) is a challenge, since pneumonia is often related to multidrug-resistant pathogens, particularly extended-spectrum β-lact...

    Hélène Carbonne, Matthieu Le Dorze, Anne-Sophie Bourrel, Hélène Poupet, Claire Poyart, Emmanuelle Cambau, Jean-Paul Mira, Julien Charpentier and Rishma Amarsy

    Annals of Intensive Care 2017 7:13

    Published on: 2 February 2017

  23. Research

    Dynamic driving pressure associated mortality in acute respiratory distress syndrome with extracorporeal membrane oxygenation

    The survival predictors and optimal mechanical ventilator settings in patients with severe acute respiratory distress syndrome (ARDS) undergoing extracorporeal membrane oxygenation (ECMO) are uncertain. This s...

    Li-Chung Chiu, Han-Chung Hu, Chen-Yiu Hung, Chih-Hao Chang, Feng-Chun Tsai, Cheng-Ta Yang, Chung-Chi Huang, Huang-Pin Wu and Kuo-Chin Kao

    Annals of Intensive Care 2017 7:12

    Published on: 25 January 2017

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