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Annals of Intensive Care
Figure 2 | Annals of Intensive Care

Figure 2

From: Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?

Figure 2

Relevant physiology required to create effective models of human metabolism for the critically ill patient. Insulin sensitivity is a whole body parameter representing is the average of the insulin resistance of each particular organ, which are all differentially regulated in stress conditions, and thus the dashed line indicates insulin-mediated uptake. Its value is patient-specific and can vary hourly [48, 73].

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