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Table 2 RIFLE classification (serum creatinine and GFR criteria)

From: Renal and neurological side effects of colistin in critically ill patients

Category Criteria
Risk (R) Increased creatinine level × 1.5 or GFR decrease >25%
Injury (I) Increased creatinine level × 2 or GFR decrease >50%
Failure (F) Increased creatinine level × 3, GFR decrease >75% or creatinine level >4 mg/dL
Loss (L) Persistent acute renal failure or complete loss of function for >4 weeks
ESKD (E) ESKD for >3 months
  1. GFR = glomerular filtration rate; ESKD = end-stage kidney disease