Skip to main content

Table 1 Degree of baseline acidemia and base deficit in DKA patients with bicarbonate administered

From: Bicarbonate in diabetic ketoacidosis - a systematic review

Reference Population Nature of study Mean initial blood indices
    pH Base deficit Bicarb (mmol/L)
Addis 1964 [29] A. (N = 3) Case series 6.94 Mostly unavailable
Kuzemko 1969 [30] P. (N = 6) Case series 7.05 23 8.0
Zimmet 1970 [4] A. (N = 11) Case series 7.09 24 4.4
Soler 1972 [22] A+P. (N = 18) Prospective C-C < 7.2 NR < 10.0
Krumlik 1973 [31] P. (N = 27) Case series 7.05 NR 7.6
Soler 1974 [32] A. (N = 1) Case report 6.85 NR 6.0
Munk 1974 [16] P. (N = 5) Prospective C-C 7.05 22 8.7
Assal 1974 [23] A+P. (N = 9) Retrospective C-C 7.06 NR 5.6
Keller 1975 [33] A. (N = 58)* Case series < 7.2 NR NR
Reddy 1977 [34] P. (N = 19) Case series 7.07 NR 6.5
Lutterman 1979 [17] A. (N = 12) Retrospective C-C 6.89 NR NR
Lever 1983 [18] A. (N = 52) Retrospective C-C 6.94-7.00 NR 3.4-4.3
Hale 1984 [13] A. (N = 16) RCT 6.85 NR 7.0
Morris 1986 [14] A. (N = 10) RCT 7.03 NR 3.6
Gamba 1991 [15] A. (N = 9) RCT (DB) 7.05 NR 2.9
Okuda 1996 [19] A. (N = 3) Prospective C-C 6.98 NR 2.0
Green 1998 [24] P. (N = 57) Retrospective C-C 7.02 40 NR
Viallon 1999 [20] A. (N = 24) Retrospective C-C 6.93 NR 3.1
Latif 2002 [21] A. (N = 4) Retrospective C-C 6.85 NR NR
Kamarzaman 2009 [35] A. (N = 1) Case report 6.27 41 4.0
Guneysel 2009 [36] A. (N = 1) Case report 6.82 27 8.4
  1. A = adults; P = pediatrics; N = number of patients who received bicarbonate, if breakdown available; C-C = case-control; RCT = randomized, controlled trial; DB = double-blinded; Bicarb = bicarbonate level; NR = not reported
  2. *Breakdown of patients with or without bicarbonate administered not provided
  3. Mean values provided separately for two different study centers
  4. Patients with initial pH < 6.9 were excluded from the RCT