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Table 1 Results obtained during three periods of 1 hour of controlled mechanical ventilation in 13 COPD patients during the first 24 after intubation

From: Helium in the adult critical care setting

  First period
air-oxygen
Second period
helium-oxygen
Third period
air-oxygen
Pmax, cmH2O 35.4 ± 6.7 31.6 ± 7.6* 34.9 ± 6.9
Ppl, cmH2O 22.3 ± 4.9 20.9 ± 5.5* 21.7 ± 4.7
P1 - Ppl, cmH2O 4.5 ± 2.2 4.7 ± 1.7 4.6 ± 2.3
statPEEPi, cmH2O 11.7 ± 4.0 10.3 ± 4.3* 10.9 ± 3.8
dynPEEPi, cmH2O 3.1 ± 1.0 2.7 ± 0.7* 3.0 ± 0.8
PaO2, mmHg 77 ± 12 79 ± 15 80 ± 12
PaCO2, mmHg 59 ± 12 62 ± 14 61 ± 14
VD/VT, % 71 ± 6 69 ± 5 69 ± 7
  1. Ppl = plateau pressure measured after an endinspiratory pause of 5 sec; P1 - Ppl = difference between the pressure (P1) measured after the rapid initial fall in pressure during an inspiratory pause, at the first point of zero flow, and Ppl; statPEEPi = static intrinsic PEEP; dynPEEPi = dynamic intrinsic PEEP; VD/VT = physiological dead-space
  2. Results are expressed as mean ± SD
  3. *Indicates a significant difference at the 0.05 level.