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Table 1 Overview of cited randomized studies in ICU patients with glutamine supplementation

From: Glutamine supplementation

Study Year published n MC/SC Patients EN/PN Gln adm Daily gln dose Length of treatment* Treatment benefit
Andrews [53] 2011 502 MC General ICU EN+PN iv 10-20 g 5 (1-10) None
Beale [29] 2008 55 SC General ICU EN enteral 40 g <10 Morbidity
Conejero [46] 2002 84 MC General ICU EN enteral 35 g 10 (7-25) Morbidity
Garrel [47] 2003 41 SC Burns EN enteral 26 g 30 ± 17 Mortality
Goeters [14] 2002 95 MC General ICU EN+PN iv 0.2 g/kg 17 ± 11 Mortality
Griffiths [15] 1997 84 SC General ICU PN iv 25 g 6 (2-91) Mortality
Hall [48] 2003 363 SC General ICU EN enteral 11-27 g 10 (6-16) None
Houdijk [30] 1998 72 SC Trauma EN enteral 27 g 12 ± 6 Morbidity
Jones [49] 1999 50 SC General ICU EN enteral 18 (11-21) g 11 (3-47) Morbidity
Wernerman [17] 2011 284 MC General ICU EN+PN iv 0.28 g/kg 12 (4-47) Mortality
Zhou [50] 2003 40 SC Burns EN enteral 0.35 g/kg 12 Morbidity
  1. MC = multi-center, SC = single-center, EN = enteral nutrition, PN = parenteral nutrition
  2. *Values are medians (ranges) or means ± SD