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Table 1 Overview of cited randomized studies in ICU patients with glutamine supplementation

From: Glutamine supplementation

Study

Year published

n

MC/SC

Patients

EN/PN

Gln adm

Daily gln dose

Length of treatment*

Treatment benefit

Andrews [53]

2011

502

MC

General ICU

EN+PN

iv

10-20 g

5 (1-10)

None

Beale [29]

2008

55

SC

General ICU

EN

enteral

40 g

<10

Morbidity

Conejero [46]

2002

84

MC

General ICU

EN

enteral

35 g

10 (7-25)

Morbidity

Garrel [47]

2003

41

SC

Burns

EN

enteral

26 g

30 ± 17

Mortality

Goeters [14]

2002

95

MC

General ICU

EN+PN

iv

0.2 g/kg

17 ± 11

Mortality

Griffiths [15]

1997

84

SC

General ICU

PN

iv

25 g

6 (2-91)

Mortality

Hall [48]

2003

363

SC

General ICU

EN

enteral

11-27 g

10 (6-16)

None

Houdijk [30]

1998

72

SC

Trauma

EN

enteral

27 g

12 ± 6

Morbidity

Jones [49]

1999

50

SC

General ICU

EN

enteral

18 (11-21) g

11 (3-47)

Morbidity

Wernerman [17]

2011

284

MC

General ICU

EN+PN

iv

0.28 g/kg

12 (4-47)

Mortality

Zhou [50]

2003

40

SC

Burns

EN

enteral

0.35 g/kg

12

Morbidity

  1. MC = multi-center, SC = single-center, EN = enteral nutrition, PN = parenteral nutrition
  2. *Values are medians (ranges) or means ± SD