Retrospective evaluation of possible renal toxicity associated with continuous infusion of vancomycin in critically ill patients

Annals of Intensive Care

Table 1 Patient characteristics

Variable	No AKI (n = 91)	AKI (n = 38)	P value
SAPS 3	67 ± 15	68 ± 14	0.63
Age, yrs	60.8 ± 14.6	62.6 ± 15.9	0.53
Weight, kg	70.5 ± 15.2	77.3 ± 15.0	0.02*
Gender, % male	51.6	60.5
Concomitant medication
Aminoglycosides, n (%)	39 (43)	12 (32)	0.32
ACEi or AT-IIra, n (%)	17 (19)	7 (18)	1
NSAIDs, n (%)	4 (4)	1 (3)	1
Immunosuppressants, n (%)	2 (2)	0 (0)	1
Comorbidities
Diabetes, n (%)	49 (54)	30 (79)	0.01*
Shock, n (%)	54 (59)	33 (87)	0.002*

AKI = acute kidney injury; SAPS = Simplified Acute Physiology Score; ACEi = angiotensin converting enzyme inhibitors; AT-IIra = angiotensin-II receptor antagonists; NSAIDs = non steroidal anti-inflammatory drugs
* P level < 0,05 is considered significant