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Table 1 Studies that have reported alterations in sublingual microcirculation in patients with severe sepsis and septic shock

From: Microcirculatory alterations: potential mechanisms and implications for therapy

Reference No. of patients Intervention
De Backer et al. AJRCCM 2002 50 Topical acetylcholine
Spronk et al. Lancet 2002 6 Nitroglycerin
Sakr et al. CCM 2004 49 Sequential assessment
De Backer et al. CCM 2006 22 Dobutamine
De Backer et al. CCM 2006 40 Activated protein C
Creteur et al. ICM 2006 18 Dobutamine
Boerma et al. CCM 2007 23 Sequential assessment
Trzeciak et al. Ann Emerg Med 2007 26 None
Sakr et al. CCM 2007 35 Transfusions
Trzeciak et al. ICM 2008 33 Goal directed therapy
Boerma et al. ICM 2008 35 None
Jhanji et al. ICM 2009 16 Norepinephrine
Dubin et al. Crit Care 2009 20 Norepinephrine
Buchele et al. CCM 2009 20 Hydrocortisone
Boerma et al. CCM 2010 70 Nitroglycerin
Ospina et al. ICM 2010 60 Fluids
Spanos et al. Shock 2010 48 None
Pottecher et al. ICM 2010 25 Fluids
Morelli et al. Crit Care 2010 40 Levosimendan
Ruiz et al. Crit Care 2010 12 High flow hemofiltration
Dubin et al. J Crit Care 2010 20 Fluids
Morelli et al. ICM 2011 20 Terlipressin