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Table 1 Sources and biological effect of investigated inflammatory mediators

From: The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study

Inflammatory mediator Abbreviation Major cell sources Major activity
Interleukin 6 IL-6 T cells, macrophages Mediator of fever and acute phase response. Has both pro- and anti-inflammatory properties
Interleukin 8 IL-8 Macrophages, epithelium, endothelium Mediator inflammatory response. Chemotactic mainly for neutrophils
Interleukin 10 IL-10 Monocytes, lymphocytes Anti-inflammatory, inhibits synthesis various pro-inflammatory cytokines
Intercellular adhesion molecule 1 ICAM-1 Leucocytes, endothelium Facilitates leucocyte endothelial transmigration, signal transduction pro-inflammatory pathways
Monocyte chemoattractant protein 1 MCP-1 Monocytes, endothelium, smooth muscle cells Chemotactic mainly for monocytes
Tissue factor TF Subendothelial tissue, platelets, leucocytes Initiation coagulation cascade, intracellular signalling (angiogenesis, apoptosis)
Cluster of differentiation molecule 11b CD11b Monocytes, neutrophils, macrophages, natural killer cells Regulates leucocyte adhesion and migration, implicated in phagocytosis and cell mediated cytotoxicity
L-selectin L-selectin Leucocytes Adhesion and homing receptor for leucocytes to enter secondary lymphoid tissues
Matrix metalloproteinase 9 MMP9 Macrophages, neutrophils, endothelium Breakdown extracellular matrix, invasion of inflammatory cells
β2 microglobulin    Housekeeping gene