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Table 1 Published studies that favor combination therapy for in-hospital patients with CAP

From: Combination antibiotic therapy for community-acquired pneumonia

Author

Year

Cohort

Site

Outcome

Study design

Gleason et al. [16]

1999

Patients aged ≥ 65 years with CAP

Ward

Lower 30-day mortality with β-lactam plus macrolide

Multicenter, retrospective

Dudas et al. [17]

2000

CAP

Ward

Lower mortality with β-lactam plus macrolide and reduced LOS

Multicenter, prospective

Waterer et al. [19]

2001

Pneumococcal bacteremia

Ward

Lower hospital mortality with combination

Multicenter, retrospective

Brown et al. [21]

2003

CAP

Ward

Lower 30-day mortality with β-lactam plus macrolide

Multicenter, retrospective

Martínez et al. [20]

2003

Pneumococcal bacteremia

Ward

Lower in-hospital mortality with β-lactam plus macrolide

Monocenter, retrospective

Baddour et al. [22]

2004

Pneumococcal bacteremia

Ward ICU

Lower 14-day mortality with combination

Multicenter, prospective

Weiss et al. [5]

2004

Pneumococcal bacteremia

Ward

Lower mortality with combination

Monocenter, retrospective

García-Vázquez et al. [23]

2005

CAP

Ward

Lower mortality with β-lactam plus macrolide

Multicenter, prospective

Mortensen et al. [24]

2006

CAP

Ward ICU

Lower 30-day mortality with β-lactam plus other than FQ

Multicenter, retrospective

Rodríguez et al. [25]

2007

CAP

ICU

Lower 28-day mortality with combination

Multicenter, retrospective

Metersky et al. [26]

2007

Pneumococcal bacteremia

Ward

Lower 30-day mortality with β-lactam plus macrolide

Multicenter, retrospective

Restrepo et al. [27]

2009

Severe sepsis pneumonia

Ward

Lower 30- and 90-day mortalities with combination plus macrolide

Multicenter, retrospective

Tessmer et al. [28]

2009

CAP

Ward

Lower 14- and 30-day mortalities with β-lactam plus macrolide

Multicenter, retrospective

Martín-Loeches et al. [29]

2010

Intubated CAP

ICU

Lower ICU mortality IDSA/ATS combination plus macrolide

Multicenter, prospective