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Table 3 Resume of recommendations for monotherapy or combination therapy in CAP

From: Combination antibiotic therapy for community-acquired pneumonia

Ambulatory setting Previously healthy patients Monotherapy
  Previous antibiotic therapy Combination or respiratory fluoroquinolone
  Comorbidities without previous antibiotic therapy Monotherapy with macrolides or respiratory fluoroquinolone
  Comorbidities and previous antibiotic therapy Combination therapy
Nursing home without hospitalization CAP Combination therapy
Hospitalized CAP Moderate disease Monotherapy with respiratory fluoroquinolones or combination therapy
  Severe CAP Combination therapy
  Bacteremic pneumococcal CAP Combination therapy
  CAP and shock Combination therapy
  Ventilation support Combination therapy