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Table 1 Analysis Comparing Pre- and Post-Dexmedetomidine Data

From: Dexmedetomidine as adjunct treatment for severe alcohol withdrawal in the ICU

Endpoint Sample size (n) for endpoint 24 h before dex First 24 H of dex therapy Decrease in values following dex initiation (percent decrease) p value 95% Confidence interval for decrease seen after dex initiation
Average Alcohol Withdrawal Scoring 11 9.0 7.1 1.9 (21.1%) 0.015 0.44–3.36(4.9%–37.3%)
Average Benzodiazepines Received (mg) 17 52.7 20.3 32.4 (61.5%) <0.001 16.7–48.1(31.7%–91.3%)
Average Haloperidol Received (mg) 17 12.0 6.4 5.6 (46.7%) 0.052 0.03–11.23(−0.36–93.6%)
Average HR 17 102.8 79.3 23.4 (22.8%) <0.001 18.4–28.4(17.9%–27.6%)
Average SBP 17 140.2 126.7 13.5 (9.6%) 0.002 5.32–21.68(3.8%–15.4%)
Hours With HR > 100 16 13.3 2.3 10.9 (82.0%) <0.001 7.4–14.4(55.6–108.3%)
Hours With SBP >140 16 11.0 6.3 4.7 (42.3%) 0.02 0.8–8.6(3.8–15.4%)
Hours With HR <60 16 0.0 2.0 −2.0 0.055 4.05–0.05
Hours With SBP <90 16 0.0 0.9 −0.9 0.079 1.89–0.09
  1. For dosing, total dose per 24 h period for each patient was averaged. For average vitals, mean values per 24 h period for each patient were averaged. For vitals outside normal range, total time outside normal range was calculated for each patient per 24 h period, and averaged. A sample size of 16 (instead of 17) was used for analyses of time spent with vitals outside normal, due to one patient having only six hours of available data. P values obtained from two-tailed paired t-tests. 95% confidence interval was calculated using t distribution for a paired sample and n-1 degrees of freedom. Dex = dexmedetomidine; SBP = systolic blood pressure; HR = heart rate.