Baseline characteristic(variable) | Associated with mortality risk only | Associated with DAA treatment selection and mortality risk | Comments |
---|---|---|---|
Age |  | √ | Increased age is associated with increased mortality [3]. Age is a variable in APACHE II [19] and SAPS II [26]; also known that DAA typically given to younger patients [18–23] |
APACHE II or SAPS II |  | √ | Both are proven predictive mortality scores; DAA typically given to patients with higher scores [18–23] |
Cardiovascular organ dysfunction |  | √ | Mortality is higher in patients with septic shock versus sepsis without shock; DAA believed to be particularly effective in patients with shock [27] |
Respiratory organ dysfunction | √ |  | |
Renal organ dysfunction | √ |  | |
Hematologic organ dysfunction |  | √ | Hematologic dysfunction increases mortality [32, 33]; DAA is particularly effective in patients with coagulopathy disorders (low platelets) [27] |
Use of mechanical ventilation | √ |  | Need for mechanical ventilation increases mortality [28, 29] |
Medical or surgical status |  | √ | Type of admission is a variable in APACHE II and SAPS II [34, 35]; recent surgery is a relative contraindication for DAA due to increased bleeding risk [7] |
Site of primary infection |  | √ | Predicted mortality varies with site of primary infection, but this is mostly a DAA selection bias variable; DAA may be particularly helpful when lung is source of primary infection [36] |