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Annals of Intensive Care
Figure 1 | Annals of Intensive Care

Figure 1

From: Statins in the critically ill

Figure 1

Effects of statins on the cholesterol biosynthesis pathway. HMG-CoA reductase inhibition by statins reduces intracellular mevalonate levels. Consequently, not only cholesterol levels are reduced but also the intermediary products farnesylpyrophosphate and geranylgeranylpyrophosphate. These latter two provide binding sites for protein isoprenylation, and activation.

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