Table 2 Effects of statins and low-dose corticosteroids versus placebo on the ventilatory status and outcome of patients with ARDS
| Â | Statins (80 mg/day) | Low-dose corticosteroids (1 mg/kg/day) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Variables | Simvastatin95(n = 30) | Placebo(n = 30) | P | Methylprednisolone96 (n = 63) | Placebo(n = 28) | P | Methylprednisolone97 (n = 55) | Placebo(n = 24) | P |
PaO2/FiO2 day 7 | 199 ± 76 | 199 ± 76 | NS | 256 ± 19 | 179 ± 21 | 0.006 |  |  |  |
LIS day 7 | 2 ± 0.78 | 2.1 ± 0.7 | NS | 2.14 ± 0.12 | 2.68 ± 0.14 | 0.004 |  |  |  |
Ventilator free days | 8.2 ± 8.1 | 9.1 ± 8.7 | NS | 16.5 ± 10.1 | 8.7 ± 10.2 | 0.001 |  |  |  |
Duration of ventilation | 18.6 ± 14.6 | 18.6 ± 14.6 | NS | 5 (3-8) | 9.5 (6-19.5) | 0.002 | 5 (0-64) | 9.5 (0-63) | 0.005 |
ICU stay | Â | Â | Â | 7 (6-12) | 14.5 (7-20.5) | 0.007 | Â | Â | Â |
ICU survival (%) | 21 (70) | 21 (70) | NS | 50 (79.4) | 16 (57.4) | 0.03 | 44 (80) | 14 (58) | 0.05 |
Hospital stay | 51.2 ± 39.3 | 48 ± 37.4 | NS | 13 (8-21) | 20.5 (10.5-40.5) | 0.09 |  |  |  |
Hospital survival (%) | 19 (63) | 19 (63) | NS | 48 (76.2) | 16 (57.1) | 0.07 | Â | Â | Â |