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Table 2 Effects of statins and low-dose corticosteroids versus placebo on the ventilatory status and outcome of patients with ARDS

From: Statins in the critically ill

  Statins (80 mg/day) Low-dose corticosteroids (1 mg/kg/day)
Variables Simvastatin95(n = 30) Placebo(n = 30) P Methylprednisolone96 (n = 63) Placebo(n = 28) P Methylprednisolone97 (n = 55) Placebo(n = 24) P
PaO2/FiO2 day 7 199 ± 76 199 ± 76 NS 256 ± 19 179 ± 21 0.006    
LIS day 7 2 ± 0.78 2.1 ± 0.7 NS 2.14 ± 0.12 2.68 ± 0.14 0.004    
Ventilator free days 8.2 ± 8.1 9.1 ± 8.7 NS 16.5 ± 10.1 8.7 ± 10.2 0.001    
Duration of ventilation 18.6 ± 14.6 18.6 ± 14.6 NS 5 (3-8) 9.5 (6-19.5) 0.002 5 (0-64) 9.5 (0-63) 0.005
ICU stay     7 (6-12) 14.5 (7-20.5) 0.007    
ICU survival (%) 21 (70) 21 (70) NS 50 (79.4) 16 (57.4) 0.03 44 (80) 14 (58) 0.05
Hospital stay 51.2 ± 39.3 48 ± 37.4 NS 13 (8-21) 20.5 (10.5-40.5) 0.09    
Hospital survival (%) 19 (63) 19 (63) NS 48 (76.2) 16 (57.1) 0.07    
  1. Data are presented as mean ± SD, no. (%), and median (interquartile range).
  2. NS not significant.