Table 1 General characteristics of the 98 HIV-infected patients admitted to the ICU
Variable (n,%) | Total | Survived the ICU | Died in the ICU | p value | |
|---|---|---|---|---|---|
(n = 98) | (n = 62) | (n = 36) | |||
Age, yr (mean ± SD) | 43.1 ± 10.7 | 43.2 ± 10.6 | 42.9 ± 10.9 | 0.815 | |
Males | 69 (70.4) | 44 (71) | 25 (69.4) | 0.873 | |
Comorbidities | |||||
Diabetes | 10 (10.2) | 8 (12.9) | 2 (5.6) | 0.316 | |
HBs Ag-positive | 14 (14.3) | 8 (12.9) | 6 (16.7) | 0.607 | |
Anti-hepatitis C virus positive | 30 (30.6) | 16 (25.8) | 14 (38.9) | 0.175 | |
Alcohol abuse | 29 (29.9) | 18 (29.0) | 11 (31.4) | 0.804 | |
Smoking | 30 (30.9) | 23 (37.1) | 11 (31.4) | 0.08 | |
Main reason for ICU admission | |||||
Acute respiratory failure | 38 (38.8) | 24 (38.7) | 14 (38.9) | 0.888 | |
Sepsis | 11 (11.2) | 6 (9.7) | 5 (13.9) | 0.57 | |
Severe neurologic disorders | 25 (25.5) | 15 (24.9) | 10 (27.8) | 0.542 | |
Miscellaneous | 24 (24.4) | 17 (27.4) | 7 (19.4) | - | |
Type of diagnosis at ICU admission | |||||
Opportunistic infection | 25 (25.5) | 16 (25.3) | 9 (25.7) | ||
Severe bacterial infection | 36 (36.7) | 22 (34.9) | 14 (40) | ||
Related to HIV | HAART-induced complications | 6 (6.1) | 5 (7.9) | 1 (2.8) | 0.975 |
Non infectious disease related to HIV | 15 (15.3) | 7 (11.1) | 8 (22.8) | ||
Total | 82 (83) | 50 (79.3) | 32 (91.4) | ||
Unrelated to HIV | 16 (16.3) | 13 (20.7) | 3 (8.6) | 0.169 | |
Details of opportunistic infection at the admission | |||||
Pneumocystis jirovecii pneumonia | 11 (11.2) | 6 (9.7) | 5 (13.9) | ||
Tuberculosis | 1 (1) | 0 | 1 (2.8) | ||
Cerebral toxoplasmosis | 6 (6.1) | 5 (8.1) | 1 (2.8) | - | |
Cryptococcosis | 3 (3.1) | 2 (3.2) | 1 (2.8) | ||
Others | 4 (4) | 3 (4.8) | 2 (5.6) | ||
No opportunistic infection | 73 (74.5) | 46 (74.2) | 27 (75) | 0.621 | |
Life-supporting procedures in ICU | |||||
Mechanical ventilation during the 24 first hours | 59 (60.2) | 28 (45.2) | 31 (86.1) | <0.001 | |
Duration of mechanical ventilation, days (mean ± SD) | 9.59 ± 17.0 | 7.61 ± 15.4 | 13 ± 19.4 | 0.003 | |
Renal replacement therapy | 15 (15.3) | 7 (11.3) | 8 (22.2) | 0.147 | |
Duration of renal replacement therapy, days (mean ± SD) | 1.7 ± 6.4 | 1.3 ± 5.3 | 2.3 ± 8.1 | 0.37 | |
Vasopressors | 51 (52) | 21 (33.9) | 30 (83.3) | <0.001 | |
Duration of vasopressors, days (mean ± SD) | 3.8 ± 6.6 | 2.6 ± 4.5 | 5.9 ± 8.8 | <0.001 | |
Length of stay in ICU, days (mean ± SD) | 14 ± 17.5 | 13.4 ± 16.1 | 15.0 ± 19.9 | 0.431 | |
Severity score (at 24 h) | |||||
SAPS II (mean ± SD) | 53.8 ± 20.7 | 46.5 ± 13.5 | 66.2 ± 24.9 | <0.001 | |
Biological data at admission | |||||
Albumin, g/L (mean ± SD) | 31.1 ± 14.2 | 32.8 ± 14.8 | 27.6 ± 12.4 | 0.125 | |
Lactic acid, mmol/l (mean ± SD) | 2.9 ± 2.9 | 2.1 ± 1.9 | 4.4 ± 3.9 | <.001 | |
Thrombin time,% (mean ± SD) | 68.4 ± 22.9 | 72.5 ± 22 | 61.6 ± 23 | 0.034 | |