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Table 1 General characteristics of the 98 HIV-infected patients admitted to the ICU

From: Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status

Variable (n,%) Total Survived the ICU Died in the ICU p value
  (n = 98) (n = 62) (n = 36)  
Age, yr (mean ± SD) 43.1 ± 10.7 43.2 ± 10.6 42.9 ± 10.9 0.815
Males 69 (70.4) 44 (71) 25 (69.4) 0.873
Comorbidities
Diabetes 10 (10.2) 8 (12.9) 2 (5.6) 0.316
HBs Ag-positive 14 (14.3) 8 (12.9) 6 (16.7) 0.607
Anti-hepatitis C virus positive 30 (30.6) 16 (25.8) 14 (38.9) 0.175
Alcohol abuse 29 (29.9) 18 (29.0) 11 (31.4) 0.804
Smoking 30 (30.9) 23 (37.1) 11 (31.4) 0.08
Main reason for ICU admission     
Acute respiratory failure 38 (38.8) 24 (38.7) 14 (38.9) 0.888
Sepsis 11 (11.2) 6 (9.7) 5 (13.9) 0.57
Severe neurologic disorders 25 (25.5) 15 (24.9) 10 (27.8) 0.542
Miscellaneous 24 (24.4) 17 (27.4) 7 (19.4) -
Type of diagnosis at ICU admission     
  Opportunistic infection 25 (25.5) 16 (25.3) 9 (25.7)  
  Severe bacterial infection 36 (36.7) 22 (34.9) 14 (40)  
Related to HIV HAART-induced complications 6 (6.1) 5 (7.9) 1 (2.8) 0.975
  Non infectious disease related to HIV 15 (15.3) 7 (11.1) 8 (22.8)  
  Total 82 (83) 50 (79.3) 32 (91.4)  
Unrelated to HIV 16 (16.3) 13 (20.7) 3 (8.6) 0.169
Details of opportunistic infection at the admission     
Pneumocystis jirovecii pneumonia 11 (11.2) 6 (9.7) 5 (13.9)  
Tuberculosis 1 (1) 0 1 (2.8)  
Cerebral toxoplasmosis 6 (6.1) 5 (8.1) 1 (2.8) -
Cryptococcosis 3 (3.1) 2 (3.2) 1 (2.8)  
Others 4 (4) 3 (4.8) 2 (5.6)
No opportunistic infection 73 (74.5) 46 (74.2) 27 (75) 0.621
Life-supporting procedures in ICU     
Mechanical ventilation during the 24 first hours 59 (60.2) 28 (45.2) 31 (86.1) <0.001
Duration of mechanical ventilation, days (mean ± SD) 9.59 ± 17.0 7.61 ± 15.4 13 ± 19.4 0.003
Renal replacement therapy 15 (15.3) 7 (11.3) 8 (22.2) 0.147
Duration of renal replacement therapy, days (mean ± SD) 1.7 ± 6.4 1.3 ± 5.3 2.3 ± 8.1 0.37
Vasopressors 51 (52) 21 (33.9) 30 (83.3) <0.001
Duration of vasopressors, days (mean ± SD) 3.8 ± 6.6 2.6 ± 4.5 5.9 ± 8.8 <0.001
Length of stay in ICU, days (mean ± SD) 14 ± 17.5 13.4 ± 16.1 15.0 ± 19.9 0.431
Severity score (at 24 h)     
SAPS II (mean ± SD) 53.8 ± 20.7 46.5 ± 13.5 66.2 ± 24.9 <0.001
Biological data at admission     
Albumin, g/L (mean ± SD) 31.1 ± 14.2 32.8 ± 14.8 27.6 ± 12.4 0.125
Lactic acid, mmol/l (mean ± SD) 2.9 ± 2.9 2.1 ± 1.9 4.4 ± 3.9 <.001
Thrombin time,% (mean ± SD) 68.4 ± 22.9 72.5 ± 22 61.6 ± 23 0.034
  1. ICU, intensive care unit; SD, standard deviation; SAPS, Simplified Acute Physiology Score; HBs Ag, hepatitis B virus surface antigen; HAART, highly active antiretroviral therapy.
  2. *p is significant.