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Table 5 Univariate and multivariate analysis of variables associated with in-ICU and 1-year mortality

From: Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status

Variables

ICU mortality

One-year mortality

 

Crude odds ratio

Adjusted odds ratio

Crude hazard ratio

Adjusted hazard ratio

 

OR [95% CI] p

OR [95% CI] p

HR [95% CI] p

HR [95% CI] p

HAART

    

No HAART at admission + no introduction in ICU

1.00 [−] -

-

1.00 [−] -

1.00 [−]

No HAART at admission + introduction in ICU

0.471 [0.087-2.533] 0.380

-

0.807 [0.277-2.355] 0.695

0.166 [0.043-0.642] 0.009

HAART active at admission and pursued

0.412 [0.118-1.438] 0.164

-

0.948 [0.446-2.014] 0.889

1.519 [0.519-4.444] 0.446

HAART active at the admission and stopped

1.947 [0.713-5.312] 0.193

-

1.827 [0.963-3.466] 0.065

1.758 [0.633-4.887] 0.279

Introducing or pursuing HAART in ICU

0.339 [0.123-0.937] 0.037

0.278 [0.082-0.939] 0.039

0.72 [0.39-1.33] 0.294

-

Immunovirological status

    

CD4 T-cell count <200 /mm3

1.332 [0.542-3.273] 0.532

-

1.348 [0.73-2.489] 0.34

-

HIV RNA load >1,000 copy/mL

1.153 [0.503-2.645]- 0.737

-

0.935 [0.541-1.616] 0.809

-

 

CD4high + VL low

1.00 [−] -

-

1.00 [−] -

1.00 [−] -

Combination

CD4high + VLhigh

2.778 [0.428-18.037] 0.857

-

2.736 [0.707-10.594] 0.145

2.344 [0.442-12.434] 0.317

 

CD4low + VLhigh

3.000 [0.578-15.583] 0.659

-

2.583 [0.77-8.670] 0.124

5.19 [1.328-20.279] 0.018

 

CD4low + VL low

5.000 [0.704-35.493] 0.208

-

7.411 [2.02-27.195] 0.002

4.714 [1.178-18.867] 0.028

Comorbidity

    

Hepatitis C virus infection

1.83 [0.760-4.406] 0.178

-

1.469 [0.829-2.603] 0.1879

3.268 [1.29-8.278] 0.012

In-ICU data

    

Use of vasoactive drugs

9.762 [3.512-27.132] <0.001

3.779 [1.11-12.861] 0.033

4.2 [2.257-7.815] <0.001

3.68 [1.394-9.716] 0.008

Mechanical ventilation

7.529 [2.585-21.923] <0.001

3.317 [0.955-11.521] 0.059

3.139 [1.64-6.007] <0.001

-

Albumin

0.97 [0.926-1.015] 0.19

-

0.968 [0.937-1.001] 0.058

-

Acid lactic in the first 24 h

1.326 [1.104-1.593] 0.002

-

1.205 [1.109-1.31] <0.001

-

SAPS II

1.06 [1.029-1.091] <0.001

1.04 [1.003-1.077] 0.032

1.065 [1.048-1.084] <0.001

1.09 [1.057-1.124] <0.001

  1. ICU, intensive care unit; CD4, lymphocyte T CD4(+); CD4high, ≥200 cell/mm3; CD4low, <200 cell/mm3; VL, viral load; VLhigh, ≥103 copy/ml; VLlow, <103 copy/ml; HAART, highly active antiretroviral therapy; OR, odds ratio; HR, hazard ratio; CI, confidence interval; SAPS, Simplified Acute Physiology Score; HBs Ag, hepatitis B virus surface antigen.
  2. *p is significant.