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Table 5 Univariate and multivariate analysis of variables associated with in-ICU and 1-year mortality

From: Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status

Variables ICU mortality One-year mortality
  Crude odds ratio Adjusted odds ratio Crude hazard ratio Adjusted hazard ratio
  OR [95% CI] p OR [95% CI] p HR [95% CI] p HR [95% CI] p
HAART     
No HAART at admission + no introduction in ICU 1.00 [−] - - 1.00 [−] - 1.00 [−]
No HAART at admission + introduction in ICU 0.471 [0.087-2.533] 0.380 - 0.807 [0.277-2.355] 0.695 0.166 [0.043-0.642] 0.009
HAART active at admission and pursued 0.412 [0.118-1.438] 0.164 - 0.948 [0.446-2.014] 0.889 1.519 [0.519-4.444] 0.446
HAART active at the admission and stopped 1.947 [0.713-5.312] 0.193 - 1.827 [0.963-3.466] 0.065 1.758 [0.633-4.887] 0.279
Introducing or pursuing HAART in ICU 0.339 [0.123-0.937] 0.037 0.278 [0.082-0.939] 0.039 0.72 [0.39-1.33] 0.294 -
Immunovirological status     
CD4 T-cell count <200 /mm3 1.332 [0.542-3.273] 0.532 - 1.348 [0.73-2.489] 0.34 -
HIV RNA load >1,000 copy/mL 1.153 [0.503-2.645]- 0.737 - 0.935 [0.541-1.616] 0.809 -
  CD4high + VL low 1.00 [−] - - 1.00 [−] - 1.00 [−] -
Combination CD4high + VLhigh 2.778 [0.428-18.037] 0.857 - 2.736 [0.707-10.594] 0.145 2.344 [0.442-12.434] 0.317
  CD4low + VLhigh 3.000 [0.578-15.583] 0.659 - 2.583 [0.77-8.670] 0.124 5.19 [1.328-20.279] 0.018
  CD4low + VL low 5.000 [0.704-35.493] 0.208 - 7.411 [2.02-27.195] 0.002 4.714 [1.178-18.867] 0.028
Comorbidity     
Hepatitis C virus infection 1.83 [0.760-4.406] 0.178 - 1.469 [0.829-2.603] 0.1879 3.268 [1.29-8.278] 0.012
In-ICU data     
Use of vasoactive drugs 9.762 [3.512-27.132] <0.001 3.779 [1.11-12.861] 0.033 4.2 [2.257-7.815] <0.001 3.68 [1.394-9.716] 0.008
Mechanical ventilation 7.529 [2.585-21.923] <0.001 3.317 [0.955-11.521] 0.059 3.139 [1.64-6.007] <0.001 -
Albumin 0.97 [0.926-1.015] 0.19 - 0.968 [0.937-1.001] 0.058 -
Acid lactic in the first 24 h 1.326 [1.104-1.593] 0.002 - 1.205 [1.109-1.31] <0.001 -
SAPS II 1.06 [1.029-1.091] <0.001 1.04 [1.003-1.077] 0.032 1.065 [1.048-1.084] <0.001 1.09 [1.057-1.124] <0.001
  1. ICU, intensive care unit; CD4, lymphocyte T CD4(+); CD4high, ≥200 cell/mm3; CD4low, <200 cell/mm3; VL, viral load; VLhigh, ≥103 copy/ml; VLlow, <103 copy/ml; HAART, highly active antiretroviral therapy; OR, odds ratio; HR, hazard ratio; CI, confidence interval; SAPS, Simplified Acute Physiology Score; HBs Ag, hepatitis B virus surface antigen.
  2. *p is significant.