Skip to main content

Table 1 Determination of drug mass flow rates for the two infusion conditions tested

From: Impact of physical incompatibility on drug mass flow rates: example of furosemide-midazolam incompatibility

  Infusion condition not leading to visible particle formation Infusion condition leading to visible particle formation
Furosemide   
Concentration in syringe (mg/mL) 2.5 10
Flow rate (mL/h) 8 2
Theoretical mass flow rate (mg/h) 20 20
Midazolam   
Concentration in syringe (mg/mL) 1 1
Flow rate (mL/h) 2 2
Theoretical mass flow rate (mg/h) 2 2
Saline flow rate (mL/h) 50 100
pH value of mixed solution at the egress of the infusion device 5.60 (±0.11) 5.62 (±0.07)
Particles   
Visible No Yes
Subvisible (in accordance with the EP threshold) Inferior Not applicable
Average number of particles ≥10 μm 18.6  
Average number of particle ≥25 μm 0.4  
Furosemide With filter Without filter With filter Without filter
Observed mass flow rate (mg/h) 18.1 (±0.77)* 18.64 (±0.28)* 17.18 (±0.7)** 17.12 (±0.63)***
Ratio Observed/Theoretical (%) 90 (±4) 93 (±1) 86 (±4) 86 (±3)
Midazolam With filter Without filter With filter Without filter
Observed mass flow rate (mg/h) 1.91 (±0.26) 1.92 (±0.24) 2.08 (±0.26) 1.98 (±0.3)
Ratio Observed/Theoretical (%) 95 (±13) 96 (±12) 104 (±13) 99 (±15)
  1. *P = 0.005 (observed vs. theoretical value).
  2. **P = 0.001 (observed vs. theoretical value).
  3. ***P < 0.001 (observed vs. theoretical value).