Table 1 Characteristics of the studies included
Characteristics | Gainnier M, 2004 7 | Forel JM, 2006 8 | Papazian L, 2010 3 | |||
|---|---|---|---|---|---|---|
NMBA | Control | NMBA | Control | NMBA | Control | |
Number of centers | Four | Three | Twenty | |||
Number of participants | 28 | 28 | 18 | 18 | 177 | 162 |
Age, years | 59.8 ± 17.5 | 61.5 ± 14.6 | 52.0 ± 16.0 | 61.0 ± 18.0 | 58.0 ± 16.0 | 58 ± 15.0 |
Lung injury score | 2.89 ± 0.40 | 2.93 ± 0.42 | 3.0 ± 0.2 | 2.8 ± 0.4 | --- | --- |
SAPS II | 41.8 ± 10.4 | 45.4 ± 10.5 | 47.0 ± 15.0 | 49.0 ± 19.0 | 50.0 ± 16.0 | 47.0 ± 14.0 |
Drug used | Cistracurium | Placebo | Cistracurium | Placebo | Cisatracurium | Placebo |
Sedation strategy | Ramsay 6* | Ramsay 6* | Ramsay 6* | Ramsay 6* | Ramsay 6* | Ramsay 6* |
Assessment of blockade | TOF | None | TOF | None | None | None |
Maximal time to randomization, hours | 36 | 36 | 48 | 48 | 48 | 48 |
Time with NMBA, hours | 48 | 48 | 48 | |||
Onset of ARDS, days | 0.96 ± 0.79 | 1.14 ± 1.72 | 1.0 ± 0.8 | 1.2 ± 0.8 | 0.75 ± 0.41 | 0.62 ± 0.32 |
Days receiving mechanical ventilation | 2.7 ± 2.6 | 3.4 ± 3.5 | --- | --- | 0.91 ± 0.87 | 0.87 ± 0.74 |
Baseline PaO2 / FiO2 | 130 ± 34 | 119 ± 31 | 105 ± 22 | 125 ± 20 | 106.0 ± 36.0 | 115.0 ± 41.0** |
Baseline PaCO2, mmHg | 48.3 ± 9.0 | 47.4 ± 11.2 | 51.1 ± 9.9 | 47.2 ± 9.8 | 47.0 ± 11.0 | 47.0 ± 11.0 |
Baseline PEEP, cmH2O | 11.1 ± 2.8 | 10.9 ± 2.4 | 13.2 ± 2.7 | 11.0 ± 2.7 | 9.2 ± 3.2 | 9.2 ± 3.5 |
Baseline VT, mL/kg | 7.1 ± 1.1 | 7.4 ± 1.9 | 6.5 ± 0.7 | 7.0 ± 0.7 | 6.55 ± 1.12 | 6.48 ± 0.92 |
Baseline FiO2, % | 70.2 ± 17.0 | 67.3 ± 15.8 | 80.0 ± 15.0 | 71.0 ± 19.0 | 79.0 ± 19.0 | 77.0 ± 22.0 |
Baseline Plateau pressure, cmH2O | 27.1 ± 6.2 | 26.1 ± 4.0 | 27.5 ± 4.4 | 24.8 ± 5.7 | 25.0 ± 5.1 | 24.4 ± 4.7 |
Time of assessment of oxygenation, hours | 120 | 120 | 120 | 120 | 168 | 168 |
Duration of mechanical ventilation, days | 20.9 ± 15.0 | 21.2 ± 17.4 | 20.0 ± 11.6 | 18.0 ± 8.3 | --- | --- |
Ventilator-free days at day 28, days | 3.7 ± 7.2 | 1.7 ± 5.3 | 6.0 ± 8.6 | 5.4 ± 6.4 | 10.6 ± 9.7 | 8.5 ± 9.4** |
Barotrauma, n (%) | 0 (0.0) | 1 (3.5) | 1 (0.0) | 1 (0.0) | 9 (5.0) | 19 (11.7)** |
Critical illness neuromyopathy, n (%) | 0 (0.0) | 0 (0.0) | 1 (5.5) | 1 (5.5) | 40 (35.7) | 28 (36.3) |
ICU mortality, n (%) | 13 (46.4) | 20 (71.4) | 5 (27.8) | 10 (55.6) | 52 (29.3) | 63 (38.8) |
Mortality at day 28 after inclusion, n (%) | 10 (37.5) | 17 (60.7) | --- | --- | 42 (23.7) | 54 (33.3)** |