Figure 3

Observed steady-state plasma and tissue concentrations for meropenem administered to critically ill patients with sepsis by intermittent bolus dosing and continuous infusion (adapted from Roberts et al. 2009, J Antimicrob Chemother). Continuous infusion (CI) meropenem plasma concentration (solid dark lines); IB meropenem plasma concentration (dotted grey lines); IB meropenem interstitial fluid concentration (ISF) (solid grey lines); CI meropenem ISF concentration (dotted dark lines).