Benefits of an early cooling phase in continuous renal replacement therapy for ICU patients

Annals of Intensive Care

Table 2 Hemodynamic variations and therapeutic interventions from H1 to H6

	Group A				Group B				P intergroup
	Period 1 temperature 38°C				Period 1 temperature 36°C
	n = 16				n = 14
	H1	H6	H6-H1	P Intra- group	H1	H6	H6-H1	P Intra-group	H6-H1
SAP mmHg	118 [26]	118 [26]	0.2 [18.9]	0.73	113 [26]	125 [20]	12.3[4.4]	0. 01	0.06
DAP mmHg	58 [13]	60 [11]	1.4 [9]	0.65	58 [9]	65 [10]	6.3 [10.6]	0.055	0.28
MAP mmHg	77 [15]	78 14]	1.2 [11.4]	0.67	71 [7]	80 [12]	8.9 [11]	0.01	0.08
HR beat/min	95 [16]	92 [18]	−3 [5.9]	0.06	103 [23]	97 [28]	−5.5 [28.3]	0.49	0.86
Lactates (mmol/L)	4.1 [3.4]	4.9 [4.5]	0.4 [2.2]	0.58	3.2 [2.3]	2.6 [2.0]	0.1 [0.3]	0.31	0.2
Nep dosage μg/kg/min	0.47 [1.19]	0.47 [1.33]	0.013 [0.2]	0.72	0.93 [0.81]	0.62 [0.56]	−0.55 [0.3]	0.04	0.15
Increase of CA dose (no. patients)	6				4
Decrease of CA dose (no. patients)	6				7
Fluid infusion (no. patients)	5				2
Total volume infused (ml)	3500				2500
Therapeutic action (no. patients)	8				5

Values are expressed as mean [SD] or median (interquartile range); SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, Nep norepinephrine, CA catecholamine. Therapeutic intervention: fluid infusion or increase dosage of catecholamine. P intragroup: H6 vs. H1.