Baseline characteristics | Influenza (n = 23) | Noninfluenza (n = 22) | p value b |
---|---|---|---|
Age (yr) | 44 ± 13 | 51 ± 17 | 0.15 |
Gender (M:F) | 10:13 | 11:11 | 0.77 |
BMI (kg/m2) | 40 ± 22 | 32 ± 12 | 0.15 |
Comorbid medical conditions | |||
Hypertension | 13 | 12 | 0.57 |
Tobacco use | 12 | 12 | 0.68 |
Chronic renal insufficiency | 1 | 6 | 0.05 |
Malignancy | 2 | 7 | 0.07 |
Immunosuppression | 4 | 6 | 0.49 |
Alcohol abuse | 1 | 6 | 0.05 |
Ischemic heart disease | 1 | 4 | 0.19 |
Cirrhosis | 0 | 4 | 0.05 |
Prior pulmonary disease | 4 | 7 | 0.31 |
Presenting symptoms to ICU | |||
Lower respiratory infection | 100% (23) | 73% (16) | 0.135 |
CNS infection | 0 | 4.5% (1) | 0.489 |
Shock requiring vasopressors | 22% (5) | 45% (10) | 0.07 |
Vital Signs | |||
SBP (mm Hg) | 131 ± 23 | 110 ± 19 | 0.004 |
DBP (mm Hg) | 71.6 ±12 | 60.5 ± 10 | 0.004 |
Temperature (°C) | 37.8 ± 1.5 | 37 ± 1.2 | 0.089 |
RR (breath/min) | 23.4 ± 8.7 | 31.7 ± 21.4 | 0.14 |
HR (beats/min) | 106 ± 27.3 | 108 ± 18 | 0.81 |
Laboratory values | |||
WBC (k/μL) | 10.6 ±7.46 | 11.4 ± 10.7 | 0.77 |
Platelets (k/μL) | 196 ± 119 | 138 ± 127 | 0.12 |
Creatinine (mg/dL) | 1.59 ± 1.13 | 1.62 ± 1.22 | 0.92 |
Bilirubin (mg/dL) | 0.65 ± 0.46 | 3.3 ± 8.3 | 0.13 |
CK (U/L) | 1155 ± 1642 | 723 ± 1551 | 0.45 |
Cause of ALI | |||
Pneumonia | 100% (23) | 41% (9) | <0.001 |
Sepsis | 0 | 23% (5) | 0.02 |
Aspiration | 0 | 9% (2) | 0.23 |
Transfusion reaction | 0 | 5% (1) | 0.49 |
Other | 0 | 23% (5) | 0.02 |
Acuity on ICU admission | |||
APACHE III score | 66 ± 20 (19) | 89 ± 32 (20) | 0.015 |
SOFA score | 8.3 ± 3.4 | 9.2 ± 4.1 | 0.44 |
Length of stay (median ± IQR) | |||
ICU length of stay (days) | 16 ± 22 | 24.5 ± 26.5 | 0.17c |
Hospital length of stay (days) | 12 ± 15 | 17 ± 25.5 | 0.45c |