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Annals of Intensive Care

Table 2 Multiparametric comparison between patients with a lactate clearance higher or lower than 10%

From: Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study

Parameters

Lactate clearance ≥10% (n = 10)

Lactate clearance <10% (n = 5)

 

Basal

End

p value a

Basal

End

p value#

Hemodynamic parameters

     

Pulse pressure variation (%)

7 (0–10)

7 (0–12)

0.1

4 (0–9)

2 (0–5)b

0.07

MAP (mmHg)

74 (66–86)

68 (65–77)

0.12

72 (64–90)

70 (64–90)

0.9

PAOP (mmHg)

14 (9–19)

11 (6–16)

0.1

16 (9–21)

13 (6–18)

0.1

CVP (mmHg)

13 (9–23)

13 (4–16)

0.1

13 (9–23)

12 (5–14)

0.7

Heart rate (bpm)

97 (80–119)

107 (65–132)

0.12

86 (74–120)

96 (74–136)

0.1

Cardiac index (l/min/m2)

3.4 (2.5-4.7)

4.1 (3–6.1)

0.2

3.1 (27–4.3)

4.2 (2.6-6.2)

0.1

APP (mmHg)

66 (54–99)

58 (48–64)

0.3

62 (50–98)

62 (48–86)

0.6

Metabolic parameters

      

PaCO2 (mmHg)

35 (30–39)

36 (30–38)

0.9

35 (28–40)

35 (31–39)

0.6

SvO2 (%)

77 (65–91)

77 (71–94)

0.2

75 (66–79)

73 (68–79)

0.07

P(cv-a)pCO2 (mmHg)

4.3 (0.7-7)

3.5 (0.2-6)

0.1

6.3 (0.8-7.7)

3.5 (1–3.8)

0.1

Peripheral perfusion parameters

      

CRT (s)

3.5 (1–7)

4 (2–6)

0.6

5 (1–12)

3 (1–12)

0.9

Central-peripheral temp. difference (°C)

8.6 (5.2-12.2)

6.5 (4–11.2)

0.06

11.8 (2.6-14)

10.5 (2.6-15.2)

0.7

NIRS-derived parameters

      

StO2 (%)

84 (55–94)

85 (77–95)

0.03

74 (72–94)

82 (69–95)

0.5

StO2 recovery slope (%/s)

1.71 (0.4-4)

2.35 (0.8-3.4)

0.3

2.3 (0.4-7.6)

0.9 (0.8-5.1)

0.7

Microcirculatory parameters

      

MFI (score)

2.1 (1.3-2.8)

1.95 (1.8-2.9)

0.9

1.87 (1–2.2)

1.92 (1.5-2.9)

0.06

Proportion of perfused vessels (%)

78.9 (62–93)

74.9 (67–99)

0.7

73.9 (40.8-82)

82.5 (71–92.1)

0.1

PVD (n/mm)

8.7 (7.5-10.7)

9.1 (6–11.3)

0.9

7.9 (4.1-10.4)

9 (7.2-10.7)

0.08

Splanchnic perfusion parameters

      

ICG-PDR (%/min)

19.9 (6.1-28)

19.6 (9–32)

0.48

14.4 (8.4-19)

9.7 (8–19)*

0.6

pCO2 gap (mmHg)

5.3 (2–10.7)

7.7 (3–58)

0.2

10.8 (5.9-61)*

33 (9.1-62)*

0.04

  1. Data presented as median (range) unless otherwise indicated.
  2. aWilcoxon test for paired measurements.
  3. b p < 0.05 by Mann–Whitney test for independent measurements comparing final values between both subgroups.
  4. MAP, mean arterial pressure; PAOP, pulmonary artery occlusion pressure; CVP, central venous pressure; APP, abdominal perfusion pressure; SvO2, mixed venous oxygen saturation; p(cv-a)CO2, mixed venous to arterial pCO2 gradient; CRT, capillary refill time; NIRS, near-infrared spectroscopy; StO2, tissue oxygen saturation; MFI, microcirculatory flow index; PVD, perfused vessel density; ICG-PDR, indocyanine green plasma disappearance rate; pCO2 gap, gastric to arterial pCO2 gradient.
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