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Table 2 Multiparametric comparison between patients with a lactate clearance higher or lower than 10%

From: Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study

Parameters Lactate clearance ≥10% (n = 10) Lactate clearance <10% (n = 5)
  Basal End p value a Basal End p value#
Hemodynamic parameters      
Pulse pressure variation (%) 7 (0–10) 7 (0–12) 0.1 4 (0–9) 2 (0–5)b 0.07
MAP (mmHg) 74 (66–86) 68 (65–77) 0.12 72 (64–90) 70 (64–90) 0.9
PAOP (mmHg) 14 (9–19) 11 (6–16) 0.1 16 (9–21) 13 (6–18) 0.1
CVP (mmHg) 13 (9–23) 13 (4–16) 0.1 13 (9–23) 12 (5–14) 0.7
Heart rate (bpm) 97 (80–119) 107 (65–132) 0.12 86 (74–120) 96 (74–136) 0.1
Cardiac index (l/min/m2) 3.4 (2.5-4.7) 4.1 (3–6.1) 0.2 3.1 (27–4.3) 4.2 (2.6-6.2) 0.1
APP (mmHg) 66 (54–99) 58 (48–64) 0.3 62 (50–98) 62 (48–86) 0.6
Metabolic parameters       
PaCO2 (mmHg) 35 (30–39) 36 (30–38) 0.9 35 (28–40) 35 (31–39) 0.6
SvO2 (%) 77 (65–91) 77 (71–94) 0.2 75 (66–79) 73 (68–79) 0.07
P(cv-a)pCO2 (mmHg) 4.3 (0.7-7) 3.5 (0.2-6) 0.1 6.3 (0.8-7.7) 3.5 (1–3.8) 0.1
Peripheral perfusion parameters       
CRT (s) 3.5 (1–7) 4 (2–6) 0.6 5 (1–12) 3 (1–12) 0.9
Central-peripheral temp. difference (°C) 8.6 (5.2-12.2) 6.5 (4–11.2) 0.06 11.8 (2.6-14) 10.5 (2.6-15.2) 0.7
NIRS-derived parameters       
StO2 (%) 84 (55–94) 85 (77–95) 0.03 74 (72–94) 82 (69–95) 0.5
StO2 recovery slope (%/s) 1.71 (0.4-4) 2.35 (0.8-3.4) 0.3 2.3 (0.4-7.6) 0.9 (0.8-5.1) 0.7
Microcirculatory parameters       
MFI (score) 2.1 (1.3-2.8) 1.95 (1.8-2.9) 0.9 1.87 (1–2.2) 1.92 (1.5-2.9) 0.06
Proportion of perfused vessels (%) 78.9 (62–93) 74.9 (67–99) 0.7 73.9 (40.8-82) 82.5 (71–92.1) 0.1
PVD (n/mm) 8.7 (7.5-10.7) 9.1 (6–11.3) 0.9 7.9 (4.1-10.4) 9 (7.2-10.7) 0.08
Splanchnic perfusion parameters       
ICG-PDR (%/min) 19.9 (6.1-28) 19.6 (9–32) 0.48 14.4 (8.4-19) 9.7 (8–19)* 0.6
pCO2 gap (mmHg) 5.3 (2–10.7) 7.7 (3–58) 0.2 10.8 (5.9-61)* 33 (9.1-62)* 0.04
  1. Data presented as median (range) unless otherwise indicated.
  2. aWilcoxon test for paired measurements.
  3. b p < 0.05 by Mann–Whitney test for independent measurements comparing final values between both subgroups.
  4. MAP, mean arterial pressure; PAOP, pulmonary artery occlusion pressure; CVP, central venous pressure; APP, abdominal perfusion pressure; SvO2, mixed venous oxygen saturation; p(cv-a)CO2, mixed venous to arterial pCO2 gradient; CRT, capillary refill time; NIRS, near-infrared spectroscopy; StO2, tissue oxygen saturation; MFI, microcirculatory flow index; PVD, perfused vessel density; ICG-PDR, indocyanine green plasma disappearance rate; pCO2 gap, gastric to arterial pCO2 gradient.