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Table 4 Characteristics of very old patients according to do-not-intubate (DNI) status

From: Results of noninvasive ventilation in very old patients

  Very old patients without DNI order (n = 59) Very old patients With DNI order (n = 39) p value
Decision of limitation    NA
Do not intubate 0 33  
Do not reintubate after extubation failure 0 6  
Age (yr) 84 (81-85) 86 (83-89) <0.01
Sex Male, n (%) 27 (46) 18 (46) 0.97
Patients living at home before hospital admission, n (%) 54 (92) 32 (82) 0.16
Charlson comorbidity index, n (%)    0.01
No or low comorbidities (0-1 point) 28 (47) 8 (21)  
High comorbidities (> 1 points) 31 (53) 31 (79)  
Type of comorbidities    
Dementia 1 (2) 6 (15) 0.02
Full dependency for ADL 0 11 (28) <0.001
End-stage respiratory failure 4 (7) 16 (41) <0.001
with home respiratory support 4 10 0.016
Active cancer 7 (12) 4 (10) 0.99
Chronic heart failure 24 (41) 17 (44) 0.77
Peripheral obstructive arterial disease 5 (8) 6 (15) 0.34
SAPS II, points 43 (36-52) 43 (36-50) 0.75
Patients with extra-respiratory OF a , n (%) 38 (64) 27 (69) 0.67
ABG before NIV start    
pH 7.36 (7.27-7.43) 7.32 (7.22-7.4) 0.18
PaCO2 (mmHg) 46 (38-64) 67 (53-80) <0.01
PaO2/FiO2 ratio (mmHg) 180 (120-268) 195 (168-216) 0.59
NIV delivery    
Within first 24 hours (h) 6 (4-8) 9 (6-15) <0.001
During ICU stay (d) 2 (1-3) 4 (3-6) <0.001
Continuing need for NIV on day 6, n (%) 3 (5) 12 (33) 0.011
ICU length of stay (d) 8 (5-13) 8 (5-14) 0.87
Among survivors 8 (5-13) 7 (5-14) 0.48
Hospital length of stay (d) 25 (13-40) 20 (8-37) 0.21
Among survivors 27 (17-40) 29 (17-45) 0.25
  1. ADL, activities of daily living; ABG, arterial blood gases. aOrgan failure (OF) is defined by at least one point in the nonrespiratory SOFA score.