Table 2 Comparison of comorbidities, subsets of circulating white blood cells, and neutrophil CD64 expression between not-at-risk drinkers with no infection, not-at-risk drinkers with infection, at-risk drinkers with no infection, and at-risk drinkers with infection

Comorbidities, n (%)

Underweight

-

7 (11)

14 (12)

6 (11)

4 (8)

0.87

Alcoholic cirrhosis

-

4 (6)

8 (7)

8 (15)

5 (10)

0.27

Current smoking

-

17 (26)

19 (17)

27 (56)

34 (68)

<0.0001

Poor dental state

-

7 (11)

11 (10)

15 (28)

15 (30)

0.0006

Antibiotics before admission, n (%)

5 (8)

61 (55)

5 (5)

30 (60)

<0.0001

Circulating white blood cells, x 10⁹/L (interquartile ranges)

Neutrophils

3.8 (0.34-0.64)*

9.65 (6.78–12.93)

12.56 (5.15–17.73)

10.06 (5.71–15.31)

9.94 (6.83–14.47)

<0 .0001

B lymphocytes

0.43 (0.32-0.5)*

0.23 (0.88–0.41)**

0.16 (0.8–0.3)

0.12 (0.06–0.19)

0.15 (0.09–0.22)

<0 .0001

Noncytotoxic T lymphocytes

1.82 (1.62-2.27)*

0.71 (0.38–1.37)**

0.51 (0.21–0.85)

0.52 (0.38–0.78)

0.46 (0.27–1.42)

<0.0001

Cytotoxic T lymphocytes

0.3 (0.22-0.36)*

0.1 (0.05–0.18)**

0.05 (0.3–0.1)

0.06 (0.04–0.14)

0.05 (0.02–0.08)

<0 .0001

Natural killer lymphocytes

0.04 (0.03-0.05)

0.04 (0.02–0.08)*

0.04 (0.02–0.07)

0.04 (0.02–0.06)

0.04 (0.02–0.07)

0.75

CD16-negative monocytes

0.52 (0.44-0.56)*

0.86 (0.53–1.3)*

0.67 (0.34–1.33)

0.65 (0.43–1.11)

0.52 (0.22–1.13)

0.008

CD16-positive monocytes

0.06 (0.04-0.07)*

0.09 (0.05–0.16)

0.11 (0.04–0.21)

0.1 (0.06–0.18)

0.11 (0.03–0.16)

0.06

Immature granulocytes

0.08 (0.04-0.12)

0.05 (0.02–0.34)

0.05 (0.02–0.24)

0.06 (0.02–0.24)

0.08 (0.02–0.18)

0.80

Neutrophil CD64 index

-

1.02 (0.83–1.35)

2.25 (1.3–4.54)***

1.14 (0.93–1.55)

2.5 (1.09–4.43)***

<0.0001

Neutrophil CD64 index >2, n (%)

-

9 (14)

61 (54)

7 (13)

28 (56)

<0.0001