|
Age (years)
|
63.2 ± 14.2
|
65.3 ± 15.2
|
0.436
|
|
Male sex (%)
|
66
|
67
|
0.798
|
|
BMI (kg/m2)
|
26.6 ± 6.6
|
24.6 ± 4.0
|
0.053
|
|
Primary reason for MV (%)
| | |
0.937
|
|
Sepsis/septic shock
|
24.1
|
24.7
| |
|
Pneumonia
|
15.5
|
16.9
| |
|
ARDS
|
13.7
|
10.8
| |
|
Postoperative/trauma
|
5.4
|
6.1
| |
|
Acute COPD exacerbation
|
6.9
|
7.7
| |
|
Congestive heart failure
|
6.9
|
6.2
| |
|
Cardiac arrest
|
5.2
|
6.2
| |
|
Hemorrhagic stroke
|
8.6
|
7.6
| |
|
Other
|
13.7
|
13.8
| |
|
Medical ICU (%)
|
40.7
|
48.0
|
0.562
|
|
ICU stay (day)
|
31.8 ± 18.1
|
11.0 ± 6.4
|
<0.001
|
|
Severity of disease
|
|
SAPS II
|
49.5 ± 15.6
|
53.9 ± 18.1
|
0.157
|
|
APACHE II
|
22.1 ± 8.5
|
23.0 ± 10.7
|
0.617
|
|
SOFA score at admission
|
10.3 ± 4.3
|
10.4 ± 4.5
|
0.844
|
|
Acute lung injury (%)
| | |
0.836
|
|
Primary
|
27.5
|
30.7
| |
|
Secondary
|
25.8
|
21.5
| |
|
Organ function assessment
|
|
Number of organs failing
|
2.2 ± 1.3
|
2.1 ± 1.2
|
0.605
|
|
Hemodynamic variables
|
|
HR (bpm)
|
96.7 ± 20.4
|
98.6 ± 18.8
|
0.661
|
|
Mean arterial pressure (mmHg)
|
84.2 ± 13.4
|
78.7 ± 10.4
|
0.011
|
|
Met shock criteria (%)
|
69.0
|
69.2
|
0.975
|
|
Vasopressor use (%)
|
69.0
|
67.8
|
0.880
|
|
CI (L/min/m2)
|
3.6 ± 1.1
|
3.1 ± 1.6
|
0.255
|
|
SVV (%)
|
11.8 ± 7.1
|
14.4 ± 6.9
|
0.236
|
|
GEF (%)
|
21.2 ± 8.1
|
15.1 ± 7.7
|
0.015
|
|
GEDVI (mL/m2)
|
766.2 ± 165.0
|
725.6 ± 174.5
|
0.42
|
|
EVLWI (mL/kg)
|
9.8 ± 3.9
|
10.5 ± 5.2
|
0.543
|
|
PVPI
|
2.4 ± 0.9
|
2.4 ± 1.1
|
0.869
|
|
Respiratory variables
|
|
Tidal volume (mL/kg of PBW)
|
8.2 ± 1.7
|
8.3 ± 1.7
|
0.709
|
|
Plateau pressure (cmH2O)
|
23.8 ± 6.5
|
24.1 ± 8.2
|
0.792
|
|
PEEP (cmH2O)
|
7.0 ± 2.2
|
6.2 ± 2.3
|
0.075
|
|
Dynamic compliance (mL/cmH2O)
|
40.9 ± 15.6
|
39.0 ± 22.6
|
0.635
|
|
PaO2/FIO2
|
263.4 ± 135.1
|
271.7 ± 154.9
|
0.755
|
|
Renal and metabolic variables
|
|
Creatinine (mg/dL)
|
1.8 ± 1.7
|
2.5 ± 2.9
|
0.095
|
|
Urine output (mL/day)
|
1,524.6 ± 1,342.7
|
1,428.5 ± 1,236.6
|
0.683
|
|
Albumin (mg/dL)
|
25.0 ± 7.5
|
27.0 ± 8.7
|
0.194
|
|
pH
|
7.35 ± 0.11
|
7.32 ± 0.12
|
0.205
|
|
Immune system
|
|
CRP (mg/dL)
|
10.6 ± 9.8
|
13.8 ± 12.4
|
0.127
|
|
Central nervous system
|
|
Glasgow Coma Score
|
8.1 ± 5.1
|
8.2 ± 5.2
|
0.905
|
|
Capillary leak index
|
52.7 ± 56.2
|
61.8 ± 61.3
|
0.411
|
|
Intra-abdominal pressure (mmHg)
|
8.2 ± 3.5
|
7.9 ± 3.7
|
0.722
|
|
Abdominal perfusion pressure (mmHg)
|
75.4 ± 13.9
|
70.4 ± 11.3
|
0.071
|
|
Fluid balance (mL/day)
|
1,755.9 ± 4,616.0
|
2,133.8 ± 3,525.1
|
0.612
|
