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Table 1 Baseline characteristics

From: Fluid management in critically ill patients: the role of extravascular lung water, abdominal hypertension, capillary leak, and fluid balance

Variable Survivors (n= 58) Nonsurvivors (n= 65) p value
Age (years) 63.2 ± 14.2 65.3 ± 15.2 0.436
Male sex (%) 66 67 0.798
BMI (kg/m2) 26.6 ± 6.6 24.6 ± 4.0 0.053
Primary reason for MV (%)    0.937
   Sepsis/septic shock 24.1 24.7  
   Pneumonia 15.5 16.9  
   ARDS 13.7 10.8  
   Postoperative/trauma 5.4 6.1  
   Acute COPD exacerbation 6.9 7.7  
   Congestive heart failure 6.9 6.2  
   Cardiac arrest 5.2 6.2  
   Hemorrhagic stroke 8.6 7.6  
   Other 13.7 13.8  
Medical ICU (%) 40.7 48.0 0.562
ICU stay (day) 31.8 ± 18.1 11.0 ± 6.4 <0.001
Severity of disease
   SAPS II 49.5 ± 15.6 53.9 ± 18.1 0.157
   APACHE II 22.1 ± 8.5 23.0 ± 10.7 0.617
   SOFA score at admission 10.3 ± 4.3 10.4 ± 4.5 0.844
Acute lung injury (%)    0.836
   Primary 27.5 30.7  
   Secondary 25.8 21.5  
Organ function assessment
   Number of organs failing 2.2 ± 1.3 2.1 ± 1.2 0.605
Hemodynamic variables
   HR (bpm) 96.7 ± 20.4 98.6 ± 18.8 0.661
   Mean arterial pressure (mmHg) 84.2 ± 13.4 78.7 ± 10.4 0.011
   Met shock criteria (%) 69.0 69.2 0.975
   Vasopressor use (%) 69.0 67.8 0.880
   CI (L/min/m2) 3.6 ± 1.1 3.1 ± 1.6 0.255
   SVV (%) 11.8 ± 7.1 14.4 ± 6.9 0.236
   GEF (%) 21.2 ± 8.1 15.1 ± 7.7 0.015
   GEDVI (mL/m2) 766.2 ± 165.0 725.6 ± 174.5 0.42
   EVLWI (mL/kg) 9.8 ± 3.9 10.5 ± 5.2 0.543
   PVPI 2.4 ± 0.9 2.4 ± 1.1 0.869
Respiratory variables
   Tidal volume (mL/kg of PBW) 8.2 ± 1.7 8.3 ± 1.7 0.709
   Plateau pressure (cmH2O) 23.8 ± 6.5 24.1 ± 8.2 0.792
   PEEP (cmH2O) 7.0 ± 2.2 6.2 ± 2.3 0.075
   Dynamic compliance (mL/cmH2O) 40.9 ± 15.6 39.0 ± 22.6 0.635
   PaO2/FIO2 263.4 ± 135.1 271.7 ± 154.9 0.755
Renal and metabolic variables
   Creatinine (mg/dL) 1.8 ± 1.7 2.5 ± 2.9 0.095
   Urine output (mL/day) 1,524.6 ± 1,342.7 1,428.5 ± 1,236.6 0.683
   Albumin (mg/dL) 25.0 ± 7.5 27.0 ± 8.7 0.194
   pH 7.35 ± 0.11 7.32 ± 0.12 0.205
Immune system
   CRP (mg/dL) 10.6 ± 9.8 13.8 ± 12.4 0.127
   Central nervous system
   Glasgow Coma Score 8.1 ± 5.1 8.2 ± 5.2 0.905
Capillary leak index 52.7 ± 56.2 61.8 ± 61.3 0.411
Intra-abdominal pressure (mmHg) 8.2 ± 3.5 7.9 ± 3.7 0.722
Abdominal perfusion pressure (mmHg) 75.4 ± 13.9 70.4 ± 11.3 0.071
Fluid balance (mL/day) 1,755.9 ± 4,616.0 2,133.8 ± 3,525.1 0.612
  1. BMI, body mass index; MV, mechanical ventilation; ARDS, acute respiratory distress syndrome; COPD, chronic obstructive pulmonary disease; SAPS, simplified acute physiology score; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; HR, heart rate; CI, cardiac index; SVV, stroke volume variation; GEF, global ejection fraction; GEDVI, global end-diastolic volume index; EVLWI, extravascular lung water index; PVPI, pulmonary vascular permeability index; PBW, predicted body weight; PEEP, positive end-expiratory pressure; CRP, C-reactive protein.