Fluid management in critically ill patients: the role of extravascular lung water, abdominal hypertension, capillary leak, and fluid balance

Annals of Intensive Care

Table 3 Analysis by IAH

Variable (1 week after ICU admission)	No IAH (n= 64)	IAH (n= 21)	p value
SOFA score
Respiratory	1.5 ± 1.5	1.7 ± 1.8	0.374
Nervous	2.4 ± 1.6	3.5 ± 1.0	0.004
Cardiovascular	2.0 ± 1.6	2.7 ± 1.3	0.092
Liver	0.6 ± 1.0	1.2 ± 1.4	0.038
Coagulation	0.8 ± 1.1	1.3 ± 1.1	0.084
Renal	1.1 ± 1.5	2.4 ± 1.8	0.002
Total	8.3 ± 4.9	12.8 ± 4.9	0.001
Respiratory variables
Tidal volume (mL/kg of PBW)	8.9 ± 2	8.4 ± 2.3	0.343
Plateau pressure (cmH₂O)	24.4 ± 6.9	29.1 ± 6	0.010
PEEP (cmH₂O)	7.3 ± 2.9	10.2 ± 3.7	0.001
Dynamic compliance (mL/cmH₂O)	43.9 ± 24.2	38.4 ± 13	0.353
PaO₂/FIO₂	275.7 ± 98.4	257.8 ± 106.2	0.486
Ventilator-free days	2.1 ± 2.1	1.4 ± 2.1	0.479
Cumulative fluid balance (mL)	5,943 ± 7,125	10,176 ± 7,523	0.024
EVLWI (mL/kg)	9.8 ± 4.3	9.2 ± 3.7	0.592

IAH, intra-abdominal hypertension; SOFA, sequential organ failure assessment; PBW, predicted body weight; PEEP, positive end-expiratory pressure; EVLWI, extravascular lung water index.