Aiming for a negative fluid balance in patients with acute lung injury and increased intra-abdominal pressure: a pilot study looking at the effects of PAL-treatment

Cordemans, Colin; De laet, Inneke; Van Regenmortel, Niels; Schoonheydt, Karen; Dits, Hilde; Martin, Greg; Huber, Wolfgang; Malbrain, Manu LNG

doi:10.1186/2110-5820-2-S1-S15

Annals of Intensive Care

Table 1 Baseline characteristics

From: Aiming for a negative fluid balance in patients with acute lung injury and increased intra-abdominal pressure: a pilot study looking at the effects of PAL-treatment

Variable	Control group (n= 57)	PAL group (n= 57)	p value
Age (year)	61.4 ± 16.8	63.0 ± 14.3	0.598
Male sex (%)	73.7	66.7	0.539
BMI	25.2 ± 4.0	26.1 ± 6.0	0.366
Primary lung injury (%)			0.607
Sepsis	43.9	47.4
Pneumonia	22.8	26.3
Aspiration	12.3	8.8
Burns	5.3	7.0
Trauma	7.0	3.5
Other	8.8	7.0
Medical ICU (%)	87.7	91.2	0.344
Severity of disease
SAPS II	52.3 ± 17.3	47.9 ± 18.4	0.188
APACHE II	22.7 ± 11.1	22.9 ± 11.4	0.934
SOFA score
Respiratory	1.9 ± 1.4	2.4 ± 1.3	0.037
Coagulation	0.9 ± 1.2	1.0 ± 1.2	0.488
Liver	0.6 ± 1.0	0.8 ± 1.2	0.302
Cardiovascular	2.9 ± 1.5	3.0 ± 1.2	0.640
Nervous	2.5 ± 1.7	2.6 ± 1.6	0.867
Renal	1.5 ± 1.6	1.5 ± 1.6	0.864
Total	10.2 ± 4.2	11.3 ± 4.0	0.160
Number of organs failing	2.1 ± 1.1	2.5 ± 1.2	0.061
Hemodynamic variables
HR (bpm)	98.0 ± 18.0	96.5 ± 19.4	0.733
Mean arterial pressure (mmHg)	83.3 ± 13.5	84.9 ± 11.0	0.502
Vasopressor use (%)	58.0	52.0	0.688
CI (L/min/m²)	3.4 ± 0.9	3.8 ± 0.9	0.145
SVV (%)	15.5 ± 8.4	12.0 ± 5.5	0.088
GEF (%)	19.7 ± 6.6	22.1 ± 7.6	0.260
GEDVI (mL/m²)	736.8 ± 141.5	807.5 ± 189.3	0.163
EVLWI (mL/kg)	12.0 ± 6.1	13.4 ± 6.2	0.326
Respiratory variables
Tidal volume (mL/kg of PBW)	8.6 ± 1.8	7.9 ± 1.9	0.119
Plateau pressure (cmH₂O)	25.1 ± 9.1	25.3 ± 7.4	0.914
PEEP (cmH₂O)	6.7 ± 2.4	10.2 ± 2.9	< 0.001
Dynamic compliance (mL/cmH₂O)	39.4 ± 17.4	42.8 ± 22.4	0.402
PaO₂/FIO₂	256.5 ± 152.7	174.5 ± 84.5	0.001
Renal and metabolic variables
Creatinine (mg/dL)	2.1 ± 2.2	1.8 ± 1.5	0.393
Urine output (mL/day)	1,366 ± 1,273	1,591 ± 1,139	0.323
CRRT (%)	47.4	40.4	0.571
Albumin (g/L)	25.3 ± 8.0	26.7 ± 6.6	0.297
pH	7.33 ± 0.12	7.35 ± 0.11	0.430
Immune system
CRP (mg/dL)	14.7 ± 13.5	15.3 ± 10.1	0.806
Central nervous system
Glasgow Coma Score	8.2 ± 5.4	7.6 ± 5.1	0.557
Capillary leak index	68.9 ± 66.3	62.9 ± 48.4	0.589
Intra-abdominal pressure (mmHg)	8.0 ± 3.7	10.0 ± 4.2	0.013
Abdominal perfusion pressure (mmHg)	75.3 ± 14.0	75.1 ± 12.9	0.933
Fluid balance day before enrolment (mL)	2,504 ± 2,704	1,659 ± 4,419	0.224

BMI, body mass index; ICU, intensive care unit; SAPS, simplified acute physiology score; APACHE, acute physiology and chronic health evaluation; SOFA, sepsis and organ failure assessment; HR, heart rate; CI, cardiac index; SVV, stroke volume variation; GEF, global ejection fraction; GEDVI, global end diastolic volume index; EVLWI, extravascular lung water index; PEEP, positive end-expiratory pressure; CRRT, continuous renal replacement therapy; CRP, C-reactive protein; PBW, predicted body weight; HR, heart rate.

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