|
Age (year)
|
61.4 ± 16.8
|
63.0 ± 14.3
|
0.598
|
|
Male sex (%)
|
73.7
|
66.7
|
0.539
|
|
BMI
|
25.2 ± 4.0
|
26.1 ± 6.0
|
0.366
|
|
Primary lung injury (%)
| | |
0.607
|
|
Sepsis
|
43.9
|
47.4
| |
|
Pneumonia
|
22.8
|
26.3
| |
|
Aspiration
|
12.3
|
8.8
| |
|
Burns
|
5.3
|
7.0
| |
|
Trauma
|
7.0
|
3.5
| |
|
Other
|
8.8
|
7.0
| |
|
Medical ICU (%)
|
87.7
|
91.2
|
0.344
|
|
Severity of disease
|
|
SAPS II
|
52.3 ± 17.3
|
47.9 ± 18.4
|
0.188
|
|
APACHE II
|
22.7 ± 11.1
|
22.9 ± 11.4
|
0.934
|
|
SOFA score
|
|
Respiratory
|
1.9 ± 1.4
|
2.4 ± 1.3
|
0.037
|
|
Coagulation
|
0.9 ± 1.2
|
1.0 ± 1.2
|
0.488
|
|
Liver
|
0.6 ± 1.0
|
0.8 ± 1.2
|
0.302
|
|
Cardiovascular
|
2.9 ± 1.5
|
3.0 ± 1.2
|
0.640
|
|
Nervous
|
2.5 ± 1.7
|
2.6 ± 1.6
|
0.867
|
|
Renal
|
1.5 ± 1.6
|
1.5 ± 1.6
|
0.864
|
|
Total
|
10.2 ± 4.2
|
11.3 ± 4.0
|
0.160
|
|
Number of organs failing
|
2.1 ± 1.1
|
2.5 ± 1.2
|
0.061
|
|
Hemodynamic variables
|
|
HR (bpm)
|
98.0 ± 18.0
|
96.5 ± 19.4
|
0.733
|
|
Mean arterial pressure (mmHg)
|
83.3 ± 13.5
|
84.9 ± 11.0
|
0.502
|
|
Vasopressor use (%)
|
58.0
|
52.0
|
0.688
|
|
CI (L/min/m2)
|
3.4 ± 0.9
|
3.8 ± 0.9
|
0.145
|
|
SVV (%)
|
15.5 ± 8.4
|
12.0 ± 5.5
|
0.088
|
|
GEF (%)
|
19.7 ± 6.6
|
22.1 ± 7.6
|
0.260
|
|
GEDVI (mL/m2)
|
736.8 ± 141.5
|
807.5 ± 189.3
|
0.163
|
|
EVLWI (mL/kg)
|
12.0 ± 6.1
|
13.4 ± 6.2
|
0.326
|
|
Respiratory variables
|
|
Tidal volume (mL/kg of PBW)
|
8.6 ± 1.8
|
7.9 ± 1.9
|
0.119
|
|
Plateau pressure (cmH2O)
|
25.1 ± 9.1
|
25.3 ± 7.4
|
0.914
|
|
PEEP (cmH2O)
|
6.7 ± 2.4
|
10.2 ± 2.9
|
< 0.001
|
|
Dynamic compliance (mL/cmH2O)
|
39.4 ± 17.4
|
42.8 ± 22.4
|
0.402
|
|
PaO2/FIO2
|
256.5 ± 152.7
|
174.5 ± 84.5
|
0.001
|
|
Renal and metabolic variables
|
|
Creatinine (mg/dL)
|
2.1 ± 2.2
|
1.8 ± 1.5
|
0.393
|
|
Urine output (mL/day)
|
1,366 ± 1,273
|
1,591 ± 1,139
|
0.323
|
|
CRRT (%)
|
47.4
|
40.4
|
0.571
|
|
Albumin (g/L)
|
25.3 ± 8.0
|
26.7 ± 6.6
|
0.297
|
|
pH
|
7.33 ± 0.12
|
7.35 ± 0.11
|
0.430
|
|
Immune system
|
|
CRP (mg/dL)
|
14.7 ± 13.5
|
15.3 ± 10.1
|
0.806
|
|
Central nervous system
|
|
Glasgow Coma Score
|
8.2 ± 5.4
|
7.6 ± 5.1
|
0.557
|
|
Capillary leak index
|
68.9 ± 66.3
|
62.9 ± 48.4
|
0.589
|
|
Intra-abdominal pressure (mmHg)
|
8.0 ± 3.7
|
10.0 ± 4.2
|
0.013
|
|
Abdominal perfusion pressure (mmHg)
|
75.3 ± 14.0
|
75.1 ± 12.9
|
0.933
|
|
Fluid balance day before enrolment (mL)
|
2,504 ± 2,704
|
1,659 ± 4,419
|
0.224
|
