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Table 1 Baseline characteristics

From: Aiming for a negative fluid balance in patients with acute lung injury and increased intra-abdominal pressure: a pilot study looking at the effects of PAL-treatment

Variable Control group (n= 57) PAL group (n= 57) p value
Age (year) 61.4 ± 16.8 63.0 ± 14.3 0.598
Male sex (%) 73.7 66.7 0.539
BMI 25.2 ± 4.0 26.1 ± 6.0 0.366
Primary lung injury (%)    0.607
   Sepsis 43.9 47.4  
   Pneumonia 22.8 26.3  
   Aspiration 12.3 8.8  
   Burns 5.3 7.0  
   Trauma 7.0 3.5  
   Other 8.8 7.0  
Medical ICU (%) 87.7 91.2 0.344
Severity of disease
   SAPS II 52.3 ± 17.3 47.9 ± 18.4 0.188
   APACHE II 22.7 ± 11.1 22.9 ± 11.4 0.934
   SOFA score
Respiratory 1.9 ± 1.4 2.4 ± 1.3 0.037
Coagulation 0.9 ± 1.2 1.0 ± 1.2 0.488
Liver 0.6 ± 1.0 0.8 ± 1.2 0.302
Cardiovascular 2.9 ± 1.5 3.0 ± 1.2 0.640
Nervous 2.5 ± 1.7 2.6 ± 1.6 0.867
Renal 1.5 ± 1.6 1.5 ± 1.6 0.864
Total 10.2 ± 4.2 11.3 ± 4.0 0.160
   Number of organs failing 2.1 ± 1.1 2.5 ± 1.2 0.061
   Hemodynamic variables
HR (bpm) 98.0 ± 18.0 96.5 ± 19.4 0.733
Mean arterial pressure (mmHg) 83.3 ± 13.5 84.9 ± 11.0 0.502
Vasopressor use (%) 58.0 52.0 0.688
CI (L/min/m2) 3.4 ± 0.9 3.8 ± 0.9 0.145
SVV (%) 15.5 ± 8.4 12.0 ± 5.5 0.088
GEF (%) 19.7 ± 6.6 22.1 ± 7.6 0.260
GEDVI (mL/m2) 736.8 ± 141.5 807.5 ± 189.3 0.163
EVLWI (mL/kg) 12.0 ± 6.1 13.4 ± 6.2 0.326
   Respiratory variables
Tidal volume (mL/kg of PBW) 8.6 ± 1.8 7.9 ± 1.9 0.119
Plateau pressure (cmH2O) 25.1 ± 9.1 25.3 ± 7.4 0.914
PEEP (cmH2O) 6.7 ± 2.4 10.2 ± 2.9 < 0.001
Dynamic compliance (mL/cmH2O) 39.4 ± 17.4 42.8 ± 22.4 0.402
PaO2/FIO2 256.5 ± 152.7 174.5 ± 84.5 0.001
   Renal and metabolic variables
Creatinine (mg/dL) 2.1 ± 2.2 1.8 ± 1.5 0.393
Urine output (mL/day) 1,366 ± 1,273 1,591 ± 1,139 0.323
CRRT (%) 47.4 40.4 0.571
Albumin (g/L) 25.3 ± 8.0 26.7 ± 6.6 0.297
pH 7.33 ± 0.12 7.35 ± 0.11 0.430
   Immune system
CRP (mg/dL) 14.7 ± 13.5 15.3 ± 10.1 0.806
   Central nervous system
Glasgow Coma Score 8.2 ± 5.4 7.6 ± 5.1 0.557
Capillary leak index 68.9 ± 66.3 62.9 ± 48.4 0.589
Intra-abdominal pressure (mmHg) 8.0 ± 3.7 10.0 ± 4.2 0.013
Abdominal perfusion pressure (mmHg) 75.3 ± 14.0 75.1 ± 12.9 0.933
Fluid balance day before enrolment (mL) 2,504 ± 2,704 1,659 ± 4,419 0.224
  1. BMI, body mass index; ICU, intensive care unit; SAPS, simplified acute physiology score; APACHE, acute physiology and chronic health evaluation; SOFA, sepsis and organ failure assessment; HR, heart rate; CI, cardiac index; SVV, stroke volume variation; GEF, global ejection fraction; GEDVI, global end diastolic volume index; EVLWI, extravascular lung water index; PEEP, positive end-expiratory pressure; CRRT, continuous renal replacement therapy; CRP, C-reactive protein; PBW, predicted body weight; HR, heart rate.