Influence of two different levels of intra-abdominal hypertension on bacterial translocation in a porcine model

Annals of Intensive Care

Table 3 Hemodynamic parameters at intervals of 6 h

Parameter	Group	0 h	6 h	12 h	18 h	24 h	Unit
CI^a	IAP-30^bc,	110.6 ± 21.3	62.0 ± 25.5^bc,	44.8 ± 19.2^bc,	39.9 ± 18.7^bc,	22.5 ± 12.7^bc,	mL·min^-1·m^-2
	IAP-15^bc,	122.7 ± 43.9	95.9 ± 20.3	83.8 ± 15.1	74.9 ± 13.4^b	71.1 ± 17.9^b	L·min^-1·m^-2
	Control^bc,	110.7 ± 19.7	94.6 ± 11.4	75.9 ± 9.2^b	73.7 ± 7.3^b	82.8 ± 17.1^b	L·min^-1·m^-2
CVP^a	IAP-30^bc,	5.2 ± 2.0^bc,	13.0 ± 2.4^bc,	11.5 ± 2.0^bc,	12.0 ± 2.7^bc,	12.5 ± 2.7^bc,	mmHg^bc,
	IAP-15^bc,	4.7 ± 1.9^bc,	9.5 ± 2.0^bc,	9.9 ± 1.8^bc,	10.6 ± 4.4^bc,	9.7 ± 2.7^bc,	mmHg^bc,
	Control^bc,	4.1 ± 3.0^bc,	2.6 ± 2.0^bc,	1.9 ± 1.6^bc,	2.8 ± 2.2^bc,	3.2 ± 1.6^bc,	mmHg^bc,
EVLWI^a	IAP-30^bc,	2.7 ± 1.3	3.6 ± 1.6	4.1 ± 2.1	4.9 ± 2.0	7.3 ± 2.4^bc,	mL·kg^-1
	IAP-15^bc,	2.5 ± 1.1	4.4 ± 1.8	5.0 ± 1.2	5.2 ± 2.1	5.2 ± 1.3^bc,	mL·kg^-1
	Control	2.2 ± 0.8	2.6 ± 0.5	3.4 ± 0.8	3.2 ± 0.7	3.1 ± 1.2	mL·kg^-1
GEDVI	IAP-30^bc,	8.2 ± 1.3	6.1 ± 1.4	5.5 ± 1.7^b	5.8 ± 1.5^bc,	4.0 ± 1.7^bc,	mL·m^-2
	IAP-15^bc,	9.5 ± 2.6	9.8 ± 2.0	9.6 ± 2.2	8.0 ± 0.7	9.0 ± 1.9	mL·m^-2
	Control	8.4 ± 1.4	8.4 ± 1.4	9.4 ± 1.2	9.4 ± 2.4	10.1 ± 1.1^b	mL·m^-2

^aSignificant change during 24 h according to ANOVA and post-hoc analysis: CI (P = 0.004); CVP (P < 0.001); EVLWI (P = 0.033). ^bSignificant difference from baseline according to paired t test: CI (IAP-30, 6 h: P = 0.002; IAP-15, 18 h: P = 0.024; control, 12 h: P = 0.004); CVP (IAP-30, 6 h: P < 0.001 and IAP-15, 12 h: P = 0.002); EVLWI (IAP-30, 24 h: P = 0.017 and IAP-15, 24 h: P = 0.013); GEDVI (IAP-30, 18 h: P = 0.026 and control, 24 h: P = 0.038). ^cSignificant difference from corresponding control according to unpaired t test: CI (IAP-30, 6 h: P = 0.002); CVP (IAP-30, 6 h: P = 0.002 and IAP-15, 12 h: P = 0.002); EVLWI (IAP-30; 24 h: P = 0.014 and IAP-15, 24 h: P = 0.019); GEDVI (IAP-30, 18 h: P = 0.002). IAP-15/IAP-30: animals exposed to an IAP of 15 mmHg or 30 mmHg, respectively, lasting for 24 h (each group consisting of six animals).