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Table 9 Literature overviews of currently published animal experiments concerning bacterial translocation under the influence of IAH

From: Influence of two different levels of intra-abdominal hypertension on bacterial translocation in a porcine model

Author
[Lit.] (year)
Model, weight IAH performed via IAH
level
IAH length Additional intervention Detection of bacterial translocation (BT) Microbiologically proven bacteria
Eleftheriadis et al.
[16] (1996)
Rats,
210 to 290 g
CO2-pneumo-peritoneum 15 mmHg 1 h Decomp.+ reperf. for 3 h or 18 h 3 hb: MLN, liver, spleen
18 hb: liver, spleen
E. coli and 'other bacteria'
Diebel et al. [17] (1997) Rats,
300 to 350 g
CO2-pneumo-peritoneum 20 to 25 mmHg 1 h Maintenance of MAP by additional fluids Spleenb
n.s.: liver, spleen, peritoneum
E. coli, Enterobacter, Entercoccus, Pseudomonas and Staphylococcus spp.
Tug et al.
[53] (1998)
Dogsa,
20 to 30 kg
CO2-pneumo-peritoneum 15 mmHg 0.5 or 2 h - ns.: PVB, MLN, liver, spleen, and peritoneum Not given
Doty et al.
[38] (2002)
Pigsa,
20 to 30 kg
Instillation of saline (intra-abdominal) 30 mmHg 1 h 1. Hemorrhage 30 min
2. IAH + high-vol. fluids
3. Decomp. + reperf. for 1 h
n.s.: PVB, MLN, spleen PVB: Staphylococcus aureus, E. coli, Clostridium
MLN: E. coli, Clostridium, S. aureus, Escherichia fergusonii
Spleen: S. aureus
Polat et al.
[18] (2003)
Rats,
200 to 250 g
CO2-pneumo-peritoneum 14, 20, or 25 mmHg 1 h Decomp. + reperf. for 4 h 14 mmHg: n.s.
20 mmHgb: liver > MLN > spleen
25 mmHgb: spleen > > liver > > MLN
Gram (-) > Gram (+)
Predominating bacterium: E. coli
Cheng et al.
[15] (2003) (Chinese)
Rabbits N2-pneumo-peritoneum 10, 20, or 30 mmHg 1, 2, or 4 h - 10 mmHg: n.s. (1 h, 2 h, 4 h)
20 mmHgb: 33% (1 h), 67% (2 h), 100% (4 h)
30 mmHgb: 100% (1 h, 2 h, 4 h)
Not given
Yagci et al.
[20] (2005)
Rabbits,
2.5 to 3.0 kg
Inflation of an intra-abdominal bag 10, 15, 20, or 25 mmHg 12 h - 10 mmHgb: spleen
15 mmHgb: MLN
20 mmHgb: spleen > MLN > liver
25 mmHgb: MLN > spleen > liver
Gram (-) > Gram (+)
Predominating bacteria:
K. pneumoniae, E. coli, and
Serratia marcescens
Sukhotnik et al.
[19] (2006)
Rats,
250 to 300 g
Air-pneumo-peritoneum 15 or 25 mmHg 1 h Decomp. + reperf. for 24 h controls: 30% BT
15 mmHgb: 60% BT
25 mmHgb: 80% BT
E. coli, S. aureus, Enterococcus,
Pseudomonas, Klebsiella spp., and
Morganella morganii
Gong et al.
[62] (2009)
Rats,
250 ± 50 g
N2-pneumo-peritoneum 20 mmHg 1 h Decomp. + reperf. for 4 h ACSb: MLN > liver > spleen
ACS/Deb: MLN > > liver > > spleen
Predominating bacterium: E. coli
Kubiak et al.
[14] (2011)
Pigsa,
22 to 30 kg
Placement of fecal clot i.a. + clamping of superior mesenteric artery 20 mmHg and more 48 h - 100% bacteremia (BT) P. aeruginosa, E. coli,
K. pneumoniae, P. mirabilis
  1. aLarge-animal models (in contrast to small-animal models). bSignificant difference compared to controls; n.s., no significant difference compared to controls. ACS, abdominal compartment syndrome (group); BT, bacterial translocation; CO2, carbon dioxide; De/decomp. + reperf., decompression and following reperfusion after IAH; Gram (+)/(-), Gram-positive or Gram-negative bacteria; IAH, intra-abdominal hypertension; MLN, mesenteric lymph nodes; PB, peripheral blood; PVB, portal vein blood; spp.: not further differentiated species of bacteria; vol.: administration of fluids (volume overload).