Age of red blood cells and transfusion in critically ill patients

Annals of Intensive Care

Table 4 Multicenter, randomized, clinical trials about blood storage in critically ill adults

Authors or study name	Population	Sample size	Case criteria	Controlled criteria	Outcome	Status
Hebert et al.[51]	ICU	57	<8 days	Standard practices	Composite outcome* (pilot study)	Achieved
Aubron et al.[67]	ICU	51	Freshest compatible available RBC	Standard practices	Feasibility (pilot study)	Achieved
**RECESS (NCT00991341)	Post cardiac surgery	1434	≤10 days	≥21 days	Change in MODS	In progress
**ABLE (ISRCTN44878718)	ICU	2510	<8 days	Standard practices	90-day mortality	In progress
**TRANSFUSE (ACTRN12612000453886)	ICU excluding postcardiac surgery	5000	Freshest compatible available RBC	Standard practices	90-day mortality	In progress

RECESS, Red Cell Storage Duration Study; ABLE, Age of Blood Evaluation; TRANSFUSE, STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE; MODS multiorgan dysfunction score; **Indicates the trial is in progress.
*Included hospital mortality, serious nosocomial infections, thrombotic events with myocardial infarction and acute ischemic stroke.