From: Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
1st author and year of publication | Therapeutic intervention assessed (inclusion time window) | Mortality rate in control arm (%) | Impact on mortality | Impact on adverse events | Effect of studied therapy* |
---|---|---|---|---|---|
Rivers 2001 [2] | Early goal guided therapy (As soon as possible) | 49.2 | Decreased mortality | No difference | Better |
Bernard 2001 [3] | Drotrecogin alfa (24 h) | 30.8 | Decreased mortality | Serious bleeding event | |
Annane 2002 [6] | Hydrocortisone + fludrocortisone (3 h) | 63 | Decreased mortality | No difference | |
Cruz 2009 [7] | Polymyxin B hemoperfusion (6 h) | 53 | Decreased mortality | Cartridge clotting Hypotension and tachycardia | |
Warren 2001 [8] | Antithrombin III (6 h) | 38.7 | No difference | No difference | No difference |
Reinhart 2004 [9] | Extracorporeal endotoxin adsorber (24 h) | 26 | No difference | ||
Heinrich 2006 [10] | IG-MA enriched Ig** (not available) | 28.2 | Not available | ||
Annane 2007 [12] | Norepinephrine plus dobutamine (24 h) | 34 | No difference | ||
Russel 2008 [14] | Vasopressin (24 h) | 39 | No difference | ||
Ranieri 2012 [1] | Drotrecogin alfa (24 h) | 24.2 | No difference | ||
Opal 2013 [15] | Eritoran (12 h) | 26.9 | No difference | ||
Lopez 2004 [16] | NO synthase inhibitor LNMA (72 h) | 49 | Increased mortality | Low cardiac output | Worse |
Abraham 2005 [11] | Drotrecogin alfa (48 h) | 17 | No difference | Bleeding events | |
Brunkhorst 2008 [17] | Insulin/pentastarch (12 h) | 26 | No difference | Hypoglycemia | |
Renal failure | |||||
Coagulopathy | |||||
Sprung 2008 [18] | Hydrocortisone (72 h) | 31.5 | No difference | Increased infections events | |
Stephens 2008 [13] | G-CSF*** (24 h) | 25 | No difference | Higher rate of new organ failure | |
Patel 2010 [19] | Dopamine Early goal guided therapy | 43 | No difference | Arrhythmias | |
Annane 2010 [20] | Corticosteroid/Insulin (not available) | 45.8 | No difference | Superinfection | |
Hypoglycemia | |||||
Perner 2012 [21] | 6% HES 130/0.42 (24 h) | 43 | Increased mortality | Not available |