Outcomes | Intermittent sedation (n = 30) | Daily interruption (n = 30) | P- value |
---|---|---|---|
Ventilator-free days in 28 days, days | 25 (21, 27) | 24 (0, 26) | 0.160 |
ICU mortality, n (%) | 7 (23) | 12 (40) | 0.165 |
Hospital mortality, n (%) | 9 (30) | 13 (43.3) | 0.284 |
Delirium, n (%) | 12 (40) | 9 (30) | 0.472 |
Delirium or coma-free days, days | 6 (1,7) | 7 (3, 7) | 0.514 |
Median SAS | 3.6 (3.4, 4.0) | 3.2 (2.6, 3.7) | 0.035 |
Percentage of time on target SAS, (%) | 75 (50, 100) | 63 (42, 95) | 0.624 |
ICU length of stay, days | 11 (6, 16) | 8 (5, 19) | 0.595 |
Hospital length of stay, days | 22 (13, 38) | 15 (9, 28) | 0.099 |
Reintubation, n (%) | 1 (3) | 4 (13) | 0.161 |
Self-extubation, n (%) | 2 (7) | 1 (3) | 0.514 |
Accidental removal of catheters, n (%) | 1 (3) | 2 (7) | 0.554 |
Tracheostomy, n (%) | 1 (3) | 1 (3) | 1.000 |
Total drug dose per patient | |||
Fentanyl, μg | 300 (100, 1,520) | 1,500 (520, 4,215) | 0.004 |
Midazolam, mg | 0 (0.0,0.5) | 45 (0,201) | < 0.001 |
Propofol, mg | 0 (0.0,0.0) | 0 (0.0,0.0) | 0.799 |
Haloperidol, mg | 0 (0.0,0.0) | 0 (0.0,0.0) | 0.280 |