Ventilatory support | Group | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | P-value |
---|---|---|---|---|---|---|---|
Patients alive, n (%) | Intermittent sedation | 30 (100) | 30 (100) | 28 (93) | 25 (84) | 24 (80) | 0.999 |
Daily interruption | 30 (100) | 28 (93) | 26 (87) | 25 (84) | 24 (80) | ||
Patients on mechanical ventilation, n (%) | Intermittent sedation | 30 (100) | 19 (63) | 17 (61) | 10 (40) | 7 (29) | 0.858 |
Daily interruption | 30 (100) | 24 (86) | 15 (58) | 12 (48) | 11 (46) | ||
Pressure support, n (%) | Intermittent sedation | 28 (93) | 18 (95) | 16 (94) | 10 (100) | 7 (100) | 0.763 |
Daily interruption | 23 (77) | 20 (84) | 11 (73) | 12 (100) | 9 (82) | ||
Controlled mode, n (%) | Intermittent sedation | 2 (7) | 7 (5) | 1 (6) | 0 (0) | 0 (0) | 0.686 |
Daily interruption | 7 (23) | 4 (16) | 4 (27) | 0 (0) | 2 (18) | ||
Hemodynamic support | |||||||
Norepinephrine, n (%) | Intermittent sedation | 18 (60) | 13 (43) | 11 (39) | 2 (8) | 1 (4) | 0.405 |
Daily interruption | 10 (33) | 6 (21) | 2 (8) | 2 (8) | 2 (8) | ||
Dobutamine, n (%) | Intermittent sedation | 13 (43) | 12 (40) | 11 (39) | 7 (28) | 3 (13) | 0.917 |
Daily interruption | 4 (13) | 4 (14) | 3 (12) | 2 (8) | 0 (0) | ||
Monitoring | |||||||
Fluid balance, mL | Intermittent sedation | 935 (323, 2,134) | 960 (421, 2,189) | −21 (-671, 1,028)d | 237 (-665, 936)d | −187 (-852, 1,336)d | < 0.001c |
Daily interruption | 743 (112, 1,836) | 190 (-705, 1,172)d | −289 (-1,143, 743)d | −106 (-804, 849)d | 180 (-1,092, 1,350)d | 0.449b | |
Nursing activity scorea | Intermittent sedation | 54 (49,56) | 48 (45, 52)d | 48 (42, 52)d | 43 (38, 45)d | 39 (34, 46)d | < 0.001c |
Daily interruption | 53 (51,54) | 45 (43, 50)d | 45 (40, 52)d | 43 (37, 45)d | 38 (34, 44)d | 0.292b | |
Total SOFA score | Intermittent sedation | 9 (7,12) | 8 (4, 11) | 9 (2, 12) | 7 (2, 10)d | 7 (2, 0)d | < 0.001c |
Daily interruption | 7 (4,10) | 7 (4, 10) | 5 (3, 8)d | 4 (3, 9)d | 4 (3, 11)d | 0.545b |