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Table 3 Data about monitoring, nurses workload, ventilatory and hemodynamic support during the first five days of mechanical ventilation admission

From: Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial

Ventilatory support

Group

Day 1

Day 2

Day 3

Day 4

Day 5

P-value

Patients alive, n (%)

Intermittent sedation

30 (100)

30 (100)

28 (93)

25 (84)

24 (80)

0.999

Daily interruption

30 (100)

28 (93)

26 (87)

25 (84)

24 (80)

Patients on mechanical ventilation, n (%)

Intermittent sedation

30 (100)

19 (63)

17 (61)

10 (40)

7 (29)

0.858

Daily interruption

30 (100)

24 (86)

15 (58)

12 (48)

11 (46)

Pressure support, n (%)

Intermittent sedation

28 (93)

18 (95)

16 (94)

10 (100)

7 (100)

0.763

Daily interruption

23 (77)

20 (84)

11 (73)

12 (100)

9 (82)

Controlled mode, n (%)

Intermittent sedation

2 (7)

7 (5)

1 (6)

0 (0)

0 (0)

0.686

Daily interruption

7 (23)

4 (16)

4 (27)

0 (0)

2 (18)

Hemodynamic support

       

Norepinephrine, n (%)

Intermittent sedation

18 (60)

13 (43)

11 (39)

2 (8)

1 (4)

0.405

Daily interruption

10 (33)

6 (21)

2 (8)

2 (8)

2 (8)

Dobutamine, n (%)

Intermittent sedation

13 (43)

12 (40)

11 (39)

7 (28)

3 (13)

0.917

Daily interruption

4 (13)

4 (14)

3 (12)

2 (8)

0 (0)

Monitoring

       

Fluid balance, mL

Intermittent sedation

935 (323, 2,134)

960 (421, 2,189)

−21 (-671, 1,028)d

237 (-665, 936)d

−187 (-852, 1,336)d

< 0.001c

Daily interruption

743 (112, 1,836)

190 (-705, 1,172)d

−289 (-1,143, 743)d

−106 (-804, 849)d

180 (-1,092, 1,350)d

0.449b

Nursing activity scorea

Intermittent sedation

54 (49,56)

48 (45, 52)d

48 (42, 52)d

43 (38, 45)d

39 (34, 46)d

< 0.001c

Daily interruption

53 (51,54)

45 (43, 50)d

45 (40, 52)d

43 (37, 45)d

38 (34, 44)d

0.292b

Total SOFA score

Intermittent sedation

9 (7,12)

8 (4, 11)

9 (2, 12)

7 (2, 10)d

7 (2, 0)d

< 0.001c

 

Daily interruption

7 (4,10)

7 (4, 10)

5 (3, 8)d

4 (3, 9)d

4 (3, 11)d

0.545b

  1. aTime spent for the care of a given patient within a shift.
  2. bMixed model fixed effects-time interaction.
  3. cMixed model fixed effects-group interaction.
  4. dP < 0.05 versus first day.
  5. SOFA, sequential organ failure assessment score.