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Table 1 Anemia and outcomes in cardiac adults: observations studies

From: Anemia and red blood cell transfusion in critically ill cardiac patients

  Health problem Patients Studies Risk
Outcome   (n) (n) (95% CI)
 Meta-analyses     
 Mortalitya[14] ACS 51,449 10 aOR: 1.49 (1.24 to 1.79)
 Mortalityb[9] ACS 171,915 27 aHR: 1.49 (1.23 to 1.81)
Studies not included in the meta-analyses     
 Mortality [15] New heart failure 12,065 1 aHR: 1.34 (1.24 to 1.46)
 Mortality [16] PCI 6,116 1 aHR: 1.8 (1.3 to 2.3)
 Mortality [17] PCI 48,851 1 aOR: 2.29 (1.79 to 2.92)
 Mortality [18] Cardiac surgery 13,843 1 12.5% versus 7.5%, P = 0.014
 Mortality [19] CABG 2,102 1 aOR: 0.99 (0.98 to 1.0)
 Mortality [20] ACS 7,922 1 aOR: 1.71 (1.34 to 2.17)
Meta-analyses on other outcomes     
 Heart failurea[14] ACS 152,849 5 OR: 1.96 (1.47 to 2.62)
 Cardiogenic shocka[14] ACS 129,136 4 OR: 1.95 (1.04 to 2.64)
 Reinfarctionb[9] ACS 22,115 6 RR: 1.25 (1.02 to 1.53)
  1. ACS: acute coronary syndrome; aHR: adjusted HR; aOR: adjusted odds ratio; CABG: coronary artery bypass graft; CI: confidence interval; HR: hazard ratio; OR: odds ratio; PCI: percutaneous coronary intervention; RR: relative risk.
  2. This table reports data from two meta-analyses [9, 14] and six observational studies [1520] that were not included in these meta-analyses.
  3. aOverall, the meta analysis conducted by Liu et al. [14] included 241,293 patients enrolled in 19 studies; the analysis on mortality (10 studies) disclosed a very important heterogeneity (I2 = 84%).
  4. bOverall, the meta analysis conducted by Lawler et al. [9] included 233,144 patients. The analyses on mortality and reinfarction included 27 and 10 studies respectively; an important heterogeneity was found in both instances (I2 = 98.2% and 48.4% respectively).