Advertisement
Table 1 Characteristics of included patients
| All patients | Survivors | Non-survivors | P | |
|---|---|---|---|---|
| (n = 84) | (n = 60) | (n = 24) | ||
| Age, mean (SD) | 50.3 (17.3) | 50.3 (16.4) | 50.4 (19.5) | 0.972 |
| Male sex, n (%) | 45 (53%) | 31 (52%) | 14 (58%) | 0.755 |
| SAPS 3 score, median (IQ) | 52 (41.75;64) | 48.5 (39.5;58.75) | 60.5 (52;71.75) | 0.002 |
| SOFA score, median (IQ) | 5 (2;8.25) | 4 (2;7) | 9 (5;11.25) | < 0.001 |
| Admission due to sepsis, n (%) | 41 (48) | 24 (40) | 17 (70) | 0.020 |
| Vasopressors at admission, n (%) | 23 (27) | 11 (18) | 12 (50) | 0.007 |
| Need for renal replacement therapy, n (%) | 24 (28) | 12 (20) | 12 (50) | 0.013 |
| Comorbidities, n (%) | ||||
| Heart failure | 20 (23) | 17 (28) | 3 (12) | 0.209 |
| Diabetes | 23 (27) | 16 (27) | 7 (29) | 0.974 |
| Hypertension | 44 (52) | 34 (57) | 10 (42) | 0.316 |
| Myocardial infarction | 7 (8) | 6 (10) | 1 (4) | 0.662 |
| Stroke | 10 (12) | 5 (8) | 5 (20) | 0.220 |
| Cancer | 3 (3) | 2 (3) | 1 (4) | 0.642 |
| Rheumatic disease | 3 (3) | 1 (1) | 2 (8) | 0.402 |
| Cirrhosis | 4 (5) | 2 (3) | 2 (8) | 0.685 |
| Child-Pugh A | 2 (2) | 1 (2) | 1 (4) | 0.909 |
| Child-Pugh B/C | 2 (2) | 1 (2) | 1 (4) | 0.909 |
| Dementia | 0 (0) | 0 (0) | 0 (0) | - |
| COPD | 3 (3) | 2 (3) | 1 (4) | 0.642 |
| Chronic kidney disease | 16 (20) | 12 (20) | 4 (17) | 0.965 |
| Creatinine, mg/dL (SD) | 1.2 (0.81;2.6) | 1.14 (0.79;2.17) | 1.61 (0.87;2.85) | 0.592 |
| Lactate, mmol/L (IQ) | 1.56 (1.11;2.13) | 1.50 (1.11;1.91) | 1.72 (1.19;3.72) | 0.197 |
| Albumin, g/dL | 2.92 (0.70) | 3.20 (0.65) | 2.45 (0.59) | < 0.001 |
| Hemoglobin, g/dL | 11.0 (2.32) | 11.4 (2.20) | 10.1 (2.43) | 0.038 |
| Leukocyte count, units/mm3 | 11,480 (7,458;15,970) | 11,480 (7,615;14,180) | 11,090 (6,072;20,310) | 0.940 |
| Platelet count at admission, 103 units/mm3 | 184.5 (138.5;262.2) | 192.5 (147.5;262.2) | 156 (119.5;254.5) | 0.149 |
| Mean platelet volume at admission, fL | 10.8 (10.2;11.5) | 10.9 (10.2;11.7) | 10.8 (10.1;11.2) | 0.516 |
| Platelet count at 24 hours, 103 units/mm3a | 184 (132.5;265.5) | 190 (143.2;273.2) | 139 (115;204) | 0.031 |
| Mean platelet volume at 24 hours, fLa | 11 (10.1;11.6) | 11.0 (10.0;11.6) | 11.0 (10.3;11.6) | 0.511 |
| Platelet count at 48 hours, 103 units/mm3b | 188 (131;276) | 198 (144;293.7) | 136.5 (99.2;215.8) | 0.040 |
| Mean platelet volume at 48 hours, fLb | 11.1 (10.2;11.7) | 11.0 (10.1;11.6) | 11.2 (10.6;11.8) | 0.333 |
| Platelet count at 72 hours, 103 units/mm3c | 188 (133;263) | 208.5 (142.5;280.8) | 146 (96;229) | 0.093 |
| Mean platelet volume at 72 hours, fLc | 11.0 (10.3;11.7) | 10.6 (10.2;11.7) | 11.3 (10.7;11.7) | 0.097 |
| ΔMPV24h,%a | 0 (−1.68;2.41) | −0.81 (−1.80;1.87) | 2.04 (0;6.01) | 0.005 |
| ΔPLAT24h,%a | −4.27 (−12.71;8.83) | −2.52 (−11.74;8.82) | −6.18 (−24.84;5.85) | 0.032 |
