Table 1 Characteristics of included patients

Age, mean (SD)

50.3 (17.3)

50.3 (16.4)

50.4 (19.5)

0.972

Male sex, n (%)

45 (53%)

31 (52%)

14 (58%)

0.755

SAPS 3 score, median (IQ)

52 (41.75;64)

48.5 (39.5;58.75)

60.5 (52;71.75)

0.002

SOFA score, median (IQ)

5 (2;8.25)

4 (2;7)

9 (5;11.25)

< 0.001

Admission due to sepsis, n (%)

41 (48)

24 (40)

17 (70)

0.020

Vasopressors at admission, n (%)

23 (27)

11 (18)

12 (50)

0.007

Need for renal replacement therapy, n (%)

24 (28)

12 (20)

12 (50)

0.013

Comorbidities, n (%)

Heart failure

20 (23)

17 (28)

3 (12)

0.209

Diabetes

23 (27)

16 (27)

7 (29)

0.974

Hypertension

44 (52)

34 (57)

10 (42)

0.316

Myocardial infarction

7 (8)

6 (10)

1 (4)

0.662

Stroke

10 (12)

5 (8)

5 (20)

0.220

Cancer

3 (3)

2 (3)

1 (4)

0.642

Rheumatic disease

3 (3)

1 (1)

2 (8)

0.402

Cirrhosis

4 (5)

2 (3)

2 (8)

0.685

Child-Pugh A

2 (2)

1 (2)

1 (4)

0.909

Child-Pugh B/C

2 (2)

1 (2)

1 (4)

0.909

Dementia

0 (0)

0 (0)

0 (0)

-

COPD

3 (3)

2 (3)

1 (4)

0.642

Chronic kidney disease

16 (20)

12 (20)

4 (17)

0.965

Creatinine, mg/dL (SD)

1.2 (0.81;2.6)

1.14 (0.79;2.17)

1.61 (0.87;2.85)

0.592

Lactate, mmol/L (IQ)

1.56 (1.11;2.13)

1.50 (1.11;1.91)

1.72 (1.19;3.72)

0.197

Albumin, g/dL

2.92 (0.70)

3.20 (0.65)

2.45 (0.59)

< 0.001

Hemoglobin, g/dL

11.0 (2.32)

11.4 (2.20)

10.1 (2.43)

0.038

Leukocyte count, units/mm³

11,480 (7,458;15,970)

11,480 (7,615;14,180)

11,090 (6,072;20,310)

0.940

Platelet count at admission, 10³ units/mm³

184.5 (138.5;262.2)

192.5 (147.5;262.2)

156 (119.5;254.5)

0.149

Mean platelet volume at admission, fL

10.8 (10.2;11.5)

10.9 (10.2;11.7)

10.8 (10.1;11.2)

0.516

Platelet count at 24 hours, 10³ units/mm^3a

184 (132.5;265.5)

190 (143.2;273.2)

139 (115;204)

0.031

Mean platelet volume at 24 hours, fL^a

11 (10.1;11.6)

11.0 (10.0;11.6)

11.0 (10.3;11.6)

0.511

Platelet count at 48 hours, 10³ units/mm^3b

188 (131;276)

198 (144;293.7)

136.5 (99.2;215.8)

0.040

Mean platelet volume at 48 hours, fL^b

11.1 (10.2;11.7)

11.0 (10.1;11.6)

11.2 (10.6;11.8)

0.333

Platelet count at 72 hours, 10³ units/mm^3c

188 (133;263)

208.5 (142.5;280.8)

146 (96;229)

0.093

Mean platelet volume at 72 hours, fL^c

11.0 (10.3;11.7)

10.6 (10.2;11.7)

11.3 (10.7;11.7)

0.097

ΔMPV_24h,%^a

0 (−1.68;2.41)

−0.81 (−1.80;1.87)

2.04 (0;6.01)

0.005

ΔPLAT_24h,%^a

−4.27 (−12.71;8.83)

−2.52 (−11.74;8.82)

−6.18 (−24.84;5.85)

0.032