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Table 3 Time-course of hemodynamic variables according to fluid responsiveness status

From: Duration of hemodynamic effects of crystalloids in patients with circulatory shock after initial resuscitation

Variable T0 (baseline) T1 (30 min) T2 (60 min) T3 (90 min)
CI (L/min/m2) R 2.84 ± 0.61 3.57 ± 0.65* 3.19 ± 0.69*,+ 3.06 ± 0.70+
NR 3.40 ± 0.55 3.59 ± 0.74 3.31 ± 0.61 3.24 ± 0.55
RAP (mmHg) R 8.54 ± 3.36 10.23 ± 3.72* 9.08 ± 3.59*,+ 9.23 ± 3.54*,+
NR 7.57 ± 2.37 9.71 ± 1.98* 8.86 ± 1.95*,+ 8.86 ± 2.27*,+
PAOP (mmHg) R 8.77 ± 3.30 10.64 ± 4.03* 8.69 ± 3.2 8.89 ± 3.62
NR 8.04 ± 3.08 9.17 ± 3.06* 9.01 ± 3.30 8.26 ± 3.05
MAP (mmHg) R 74.62 ± 6.84 83.92 ± 8.20* 79.62 ± 10.94 79.77 ± 14.02
NR 72.00 ± 10.63 77.57 ± 11.36* 74.86 ± 8.84 73.57 ± 10.83
HR (beats/min) R 107.54 ± 19.83 105.77 ± 19.63 107.85 ± 20.43 108.62 ± 21.06
NR 111.71 ± 16.80 106.86 ± 16.31 106.43 ± 18.17 105.57 ± 17.42
Lactate (mmol/L) R 2.78 (1.50 to 6.89) 2.78 (1.56 to 6.72)   
NR 3.44 (2.22 to 4.22) 3.44 (2.22 to 5.11)   
Hb (g/dL) R 9.36 ± 1.76 9.34 ± 2.06   
NR 10.01 ± 1.36 8.83 ± 1.26*   
SvO2 (%) R 63.00 ± 9.08 66.30 ± 8.30*   
NR 72.46 ± 5.02 74.20 ± 4.01   
  1. R, responders; NR, non-responders; CI, cardiac index; RAP, right atrial pressure; PAOP, pulmonary artery occlusion pressure; MAP, mean arterial pressure; HR, heart rate; SvO2, mixed venous oxygen saturation; Hb, hemoglobin. The groups (R and NR) showed significant CI difference over time (p = 0.009). The CI did not change over time in NR (p = 0,306). The groups (R and NR) showed no significant difference over time in RAP, PAOP, MAP, and HR (p > 0.05). Mean values of RAP, PAOP, MAP, and HR were similar between R and NR at T0, T1, T2, and T3 (p > 0.05). The groups (R and NR) showed significant difference in SvO2 (p = 0.02) at T0. The groups (R and NR) showed no significant difference in lactate levels (p = 0.72) and Hb (p = 0.46) at T0. *p < 0.05 versus baseline, +p < 0.05 versus T1. Data are expressed as means (SD) or medians (IQR 25th to 75th percentile).