Duration of hemodynamic effects of crystalloids in patients with circulatory shock after initial resuscitation

Annals of Intensive Care

Table 3 Time-course of hemodynamic variables according to fluid responsiveness status

Variable		T0 (baseline)	T1 (30 min)	T2 (60 min)	T3 (90 min)
CI (L/min/m²)	R	2.84 ± 0.61	3.57 ± 0.65*	3.19 ± 0.69*^,+	3.06 ± 0.70⁺
CI (L/min/m²)	NR	3.40 ± 0.55	3.59 ± 0.74	3.31 ± 0.61	3.24 ± 0.55
RAP (mmHg)	R	8.54 ± 3.36	10.23 ± 3.72*	9.08 ± 3.59*^,+	9.23 ± 3.54*^,+
RAP (mmHg)	NR	7.57 ± 2.37	9.71 ± 1.98*	8.86 ± 1.95*^,+	8.86 ± 2.27*^,+
PAOP (mmHg)	R	8.77 ± 3.30	10.64 ± 4.03*	8.69 ± 3.2	8.89 ± 3.62
PAOP (mmHg)	NR	8.04 ± 3.08	9.17 ± 3.06*	9.01 ± 3.30	8.26 ± 3.05
MAP (mmHg)	R	74.62 ± 6.84	83.92 ± 8.20*	79.62 ± 10.94	79.77 ± 14.02
MAP (mmHg)	NR	72.00 ± 10.63	77.57 ± 11.36*	74.86 ± 8.84	73.57 ± 10.83
HR (beats/min)	R	107.54 ± 19.83	105.77 ± 19.63	107.85 ± 20.43	108.62 ± 21.06
HR (beats/min)	NR	111.71 ± 16.80	106.86 ± 16.31	106.43 ± 18.17	105.57 ± 17.42
Lactate (mmol/L)	R	2.78 (1.50 to 6.89)	2.78 (1.56 to 6.72)
Lactate (mmol/L)	NR	3.44 (2.22 to 4.22)	3.44 (2.22 to 5.11)
Hb (g/dL)	R	9.36 ± 1.76	9.34 ± 2.06
Hb (g/dL)	NR	10.01 ± 1.36	8.83 ± 1.26*
SvO₂ (%)	R	63.00 ± 9.08	66.30 ± 8.30*
SvO₂ (%)	NR	72.46 ± 5.02	74.20 ± 4.01

R, responders; NR, non-responders; CI, cardiac index; RAP, right atrial pressure; PAOP, pulmonary artery occlusion pressure; MAP, mean arterial pressure; HR, heart rate; SvO₂, mixed venous oxygen saturation; Hb, hemoglobin. The groups (R and NR) showed significant CI difference over time (p = 0.009). The CI did not change over time in NR (p = 0,306). The groups (R and NR) showed no significant difference over time in RAP, PAOP, MAP, and HR (p > 0.05). Mean values of RAP, PAOP, MAP, and HR were similar between R and NR at T0, T1, T2, and T3 (p > 0.05). The groups (R and NR) showed significant difference in SvO₂ (p = 0.02) at T0. The groups (R and NR) showed no significant difference in lactate levels (p = 0.72) and Hb (p = 0.46) at T0. *p < 0.05 versus baseline, ⁺p < 0.05 versus T1. Data are expressed as means (SD) or medians (IQR 25th to 75th percentile).