Table 1 Reported methodological quality of animal research published in three critical care journals in 2012: Methods section
From: The methodological quality of animal research in critical care: the public face of science
Criterion | Number of 77 publications meeting criterion,n(%) [95% confidence interval] |
|---|---|
Randomization reported | 47 (61%) [50%, 71%] |
 Allocation concealment mentioned | 3 (6% of 47) [2%, 18%] |
 Randomization procedure described | 1 (2% of 47) [<1%, 12%] |
Reported blinding of any type mentioned below | 31 (40%) [30%, 51%] |
 Disease induction | 14 (45% of 31) [29%, 62%] |
 Intervention | 7 (23% of 31) [11%, 40%] |
 Subjective outcomes | 17 (55% of 31) [38%, 71%] |
Primary outcome specified | 5 (7%) [2%, 15%] |
Sample size calculation reported | 4 (5%) [2%, 13%] |
More than 10 secondary outcomes specified | 74 (96%) [89%, 99%] |
Eligibility criteria for animals stated | 4 (5%) [2%, 13%] |
Acclimation/habituation prior to experiments stated | 6 (8%) [3%, 16%] |
Staff (number or training) performing experiment described | 1 (1%) [<1%, 8%] |
Animal numbers stated in methods section | 61 (79%) [69%, 87%] |
 Animal numbers (when stated) | Median 32 (range 6 to 320; IQR 21 to 70) |
Sepsis model: with any supportive therapy mentioneda | 12 (44% of 27) [28%, 63%] |