Pulmonary vascular dysfunction in ARDS

Annals of Intensive Care

Table 2 Studies that relate pulmonary haemodynamic variables to outcome from ARDS

	Study period	Number	PAP mmHg (mean PAP unless specified)	PVRI wood units (m⁻²)	PAOP mmHg	Independent predictors of survival
	Study period	Number	PAP mmHg (mean PAP unless specified)	PVRI wood units (m⁻²)	PAOP mmHg	PAP	PVR (I)
Zapol and Snider [9]	Pre 1977	30	28 to 32	(2.5 to 4.8)	n/a	N	Y (trend)
Villar et al. [10]	1983 to 1986	30	27 to 28 ± 4 to 7	4.5 ± 1.69 to 5.7 ± 2.06	10 ± 4 to 11 ± 5	N	Y
Squara et al. [6]	1985 to 1987	586	26 ± 8.5	3.21 ± 1.75	11.7 ± 4.5	Y	N
Suchyta et al. [11]	1987 to 1990	162	26 ± 8	n/a	n/a	N	-
Hemmila et al. [12]	1989 to 2003	255	Systolic 46 ± 13.5	n/a	17.6 ± 5	N	-
Hemmila et al. [12]	1989 to 2003	255	Diastolic 28.5 ± 8.9	n/a	17.6 ± 5	N	-
Osman et al. [13]	1999 to 2001	145	28 ± 8	4.5 ± 2.4	12 ± 5	Y	N
Cepkova et al. [8]	2004 to 2006	42	Systolic 42 ± 9			N
Cepkova et al. [8]	2004 to 2006	42	Echo derived			N
Beiderlinden et al. [14]	Pub 2006	95	35.4 ± 8.8	4.625 ± 2.04	16 ± 5.4	N	-
Bull et al. [5]	2000 to 2005	501	31.6 ± 8.3	3.825 (2.49 to 6.48)	17.13 ± 5	N	Y

All haemodynamic data was derived from pulmonary artery catheter use unless otherwise stated. mPAP, mean pulmonary artery pressure; PVRI, pulmonary vascular resistance index; PAOP, pulmonary artery occlusion pressure; PAP, pulmonary artery pressure. Wood units (mmHg/L/min) are multiplied by 80 to convert to standard metric units (dynes.sec.cm⁻⁵). Normal values for PVR range from 0.3 to 1.6 Wood unit.