From: When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring
Perfusion parameters | Number of patients with altered baseline values | Baseline | 2 h | 6 h | 24 h | pvaluea |
---|---|---|---|---|---|---|
Lactate (mmol/L) | 84 | 4.0 [3.0 to 4.9] | 3.4 [2.4 to 4.2] | 2.8 [2.0 to 3.8] | 1.8 [1.4 to 2.5] | <0.001 |
P(cv-a)CO2 (mmHg) | 34 | 8 [7 to 9] | 6 [5 to 8] | 5 [3 to 7] | 4 [3 to 6] | <0.001 |
CRT (s) | 43 | 6 [5 to 8] | 4 [3 to 5] | 3 [2 to 6] | 2 [2 to 4] | 0.001 |
ScvO2 (%) | 8 | 62 [58 to 67] | 65 [60 to 69] | 71 [70 to 74] | 74 [70 to 79] | 0.001 |
Hemodynamic parameters | Number of patients assessed | Baseline | 2 h | 6 h | 24 h | p value a |
CI (L/min/m2) | 38 | 3.1 [2.5 to 3.9] | 3.5 [2.9 to 4.6] | 3.2 [2.6 to 3.8] | 2.8 [2.4 to 4.1] | NS |
Pulse pressure variation (%) | 63 | 6 [3 to 8] | 5 [2 to 8] | 6 [2 to 8] | 5 [4 to 9] | NS |
CVP (mmHg) | 84 | 13 [9 to 17] | 14 [10 to 16] | 14 [10 to 16] | 14 [11 to 17] | NS |
MAP (mm Hg) | 84 | 73 [67 to 79] | 71 [68 to 74] | 71 [68 to 74] | 72 [70 to 77] | NS |
NE dose (mcg/kg/min) | 84 | 0.11 [0.04 to 0.3] | 0.18 [0.06 to 0.31] | 0.17 [0.07 to 0.35] | 0.05 [0 to 0.23] | NS |
IAP (mmHg) | 72 | 12 [9 to 15] | 11 [9 to 13] | 12 [9 to 12] | 11 [8 to 14] | NS |