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Table 2 Evolution of different perfusion and hemodynamic parameters in a cohort of 84 hospital survivors

From: When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring

Perfusion parameters Number of patients with altered baseline values Baseline 2 h 6 h 24 h pvaluea
Lactate (mmol/L) 84 4.0 [3.0 to 4.9] 3.4 [2.4 to 4.2] 2.8 [2.0 to 3.8] 1.8 [1.4 to 2.5] <0.001
P(cv-a)CO2 (mmHg) 34 8 [7 to 9] 6 [5 to 8] 5 [3 to 7] 4 [3 to 6] <0.001
CRT (s) 43 6 [5 to 8] 4 [3 to 5] 3 [2 to 6] 2 [2 to 4] 0.001
ScvO2 (%) 8 62 [58 to 67] 65 [60 to 69] 71 [70 to 74] 74 [70 to 79] 0.001
Hemodynamic parameters Number of patients assessed Baseline 2 h 6 h 24 h p value a
CI (L/min/m2) 38 3.1 [2.5 to 3.9] 3.5 [2.9 to 4.6] 3.2 [2.6 to 3.8] 2.8 [2.4 to 4.1] NS
Pulse pressure variation (%) 63 6 [3 to 8] 5 [2 to 8] 6 [2 to 8] 5 [4 to 9] NS
CVP (mmHg) 84 13 [9 to 17] 14 [10 to 16] 14 [10 to 16] 14 [11 to 17] NS
MAP (mm Hg) 84 73 [67 to 79] 71 [68 to 74] 71 [68 to 74] 72 [70 to 77] NS
NE dose (mcg/kg/min) 84 0.11 [0.04 to 0.3] 0.18 [0.06 to 0.31] 0.17 [0.07 to 0.35] 0.05 [0 to 0.23] NS
IAP (mmHg) 72 12 [9 to 15] 11 [9 to 13] 12 [9 to 12] 11 [8 to 14] NS
  1. Values are expressed as median [interquartile range]. aComparison within group of variables was made with non-parametric trend. p(cv-a)CO2, central venous to arterial pCO2 gradient; CRT, capillary refill time; ScvO2, central venous oxygen saturation; CI, cardiac index; CVP, central venous pressure; MAP, mean arterial pressure; NE, norepinephrine; IAP, intra-abdominal pressure.