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Table 2 Evolution of different perfusion and hemodynamic parameters in a cohort of 84 hospital survivors

From: When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring

Perfusion parameters

Number of patients with altered baseline values

Baseline

2 h

6 h

24 h

pvaluea

Lactate (mmol/L)

84

4.0 [3.0 to 4.9]

3.4 [2.4 to 4.2]

2.8 [2.0 to 3.8]

1.8 [1.4 to 2.5]

<0.001

P(cv-a)CO2 (mmHg)

34

8 [7 to 9]

6 [5 to 8]

5 [3 to 7]

4 [3 to 6]

<0.001

CRT (s)

43

6 [5 to 8]

4 [3 to 5]

3 [2 to 6]

2 [2 to 4]

0.001

ScvO2 (%)

8

62 [58 to 67]

65 [60 to 69]

71 [70 to 74]

74 [70 to 79]

0.001

Hemodynamic parameters

Number of patients assessed

Baseline

2 h

6 h

24 h

p value a

CI (L/min/m2)

38

3.1 [2.5 to 3.9]

3.5 [2.9 to 4.6]

3.2 [2.6 to 3.8]

2.8 [2.4 to 4.1]

NS

Pulse pressure variation (%)

63

6 [3 to 8]

5 [2 to 8]

6 [2 to 8]

5 [4 to 9]

NS

CVP (mmHg)

84

13 [9 to 17]

14 [10 to 16]

14 [10 to 16]

14 [11 to 17]

NS

MAP (mm Hg)

84

73 [67 to 79]

71 [68 to 74]

71 [68 to 74]

72 [70 to 77]

NS

NE dose (mcg/kg/min)

84

0.11 [0.04 to 0.3]

0.18 [0.06 to 0.31]

0.17 [0.07 to 0.35]

0.05 [0 to 0.23]

NS

IAP (mmHg)

72

12 [9 to 15]

11 [9 to 13]

12 [9 to 12]

11 [8 to 14]

NS

  1. Values are expressed as median [interquartile range]. aComparison within group of variables was made with non-parametric trend. p(cv-a)CO2, central venous to arterial pCO2 gradient; CRT, capillary refill time; ScvO2, central venous oxygen saturation; CI, cardiac index; CVP, central venous pressure; MAP, mean arterial pressure; NE, norepinephrine; IAP, intra-abdominal pressure.