Variables | NMB | No NMB | Pvalue |
---|---|---|---|
n= 431 | n= 552 | ||
Baseline characteristics | Â | Â | Â |
Age, years, mean (SD) | 54.4 (16.7) | 56.9 (16.3) | 0.02 |
Female sex, n (%) | 165 (38.3) | 229 (41.5) | 0.31 |
APACHE II score, mean (SD) | 26.7 (7.3) | 24.3 (7.9) | <0.0001 |
PaO2/FiO2, mean (SD) | 132.0 (48.5) | 154.6 (46.3) | <0.0001 |
Set PEEP, cm H2O, mean (SD) | 12.0 (3.5) | 10.7 (3.1) | <0.0001 |
Pplateau, cm H2O, mean (SD) | 30.9 (6.0) | 28.7 (5.4) | <0.0001 |
PaCO2, mean (SD) | 44.2 (11.1) | 40.7 (8.4) | <0.0001 |
pH, mean (SD) | 7.35 (0.08) | 7.38 (0.08) | <0.0001 |
Tidal volume, ml/kg PBW, mean (SD) | 8.2 (2.2) | 8.6 (2.1) | 0.01 |
Minute ventilation, l/min, mean (SD) | 11.6 (3.5) | 11.4 (3.4) | 0.20 |
Barotrauma, n (%) | 19 (4.4) | 17 (3.1) | 0.27 |
Hepatic failure/cirrhosis, n (%) | 18 (4.2) | 26 (4.7) | 0.69 |
Chronic dialysis, n (%) | 34 (7.9) | 62 (11.2) | 0.08 |
Interventions and outcomes | Â | Â | Â |
Corticosteroids during first 28 days, n (%) | 227 (52.7) | 183 (33.2) | <0.0001 |
Mechanical ventilation, days, median (IQR) | 14 (8 to 23) | 8 (5 to 12) | <0.0001 |
Hospital stay, days, median (IQR) | 24 (14 to 44) | 20 (11 to 37) | 0.01 |
Death during first 28 days, n (%) | 168 (37.0) | 131 (23.7) | <0.0001 |
Death in ICU, n (%) | 191 (44.3) | 132 (23.9) | <0.0001 |
Death during mechanical ventilation, n (%) | 185 (43.5) | 119 (22.1) | <0.0001 |
Barotraumaa, n (%) | 93 (21.6) | 69 (12.5) | 0.0001 |