A ventilator strategy combining low tidal volume ventilation, recruitment maneuvers, and high positive end-expiratory pressure does not increase sedative, opioid, or neuromuscular blocker use in adults with acute respiratory distress syndrome and may improve patient comfort

Annals of Intensive Care

Table 5 Cox's proportional-hazards regression analysis - time to neuromuscular blocker use as the outcome and stratified by center

	Adjusted HR (95% CI)	Pvalue
Baseline variables
Age, 10-year increase	1.01 (0.87, 1.17)	0.92
APACHE II score, 5-point increase	1.66 (1.04, 2.66)	0.04
Intervention versus control	1.17 (0.32, 4.30)	0.82
Sepsis	1.00 (0.51, 1.97)	0.99
Time-dependent variables
Sedative doses, 10-mg increase	1.03 (1.02, 1.05)	<0.0001
Opioid doses, 10-mg increase	1.01 (0.999, 1.02)	0.07
PEEP	0.88 (0.70, 1.11)	0.28
P _plateau	1.15 (1.07, 1.23)	0.0002
PaO₂/FiO₂, 5-point increase	1.05 (1.03, 1.08)	0.03
Tidal volume (ml/kg PBW)	0.99 (0.67, 1.47)	0.95
Barotrauma	8.54 (1.17, 62.09)	0.03

In this table, we present the multivariable Cox regression results. Both baseline and time-dependent variables were considered. APACHE II, Acute Physiology and Chronic Health Evaluation II. Sedative doses were expressed in midazolam equivalents, and opioid doses were expressed in fentanyl equivalents.