Dissociation between sublingual and gut microcirculation in the response to a fluid challenge in postoperative patients with abdominal sepsis

Annals of Intensive Care

Table 2 Systemic cardiovascular variables and tissue perfusion parameters before and after the fluid challenge

	Before	After	P
Heart rate (beats/min)	87 ± 27	86 ± 23	0.45
Mean arterial blood pressure (mm Hg)	68 ± 11	82 ± 12	<0.0001
Central venous pressure (mm Hg)	10 ± 4	12 ± 6	<0.01
Intra-abdominal pressure (mm Hg)	8 ± 3	8 ± 3	0.33
Abdominal perfusion pressure (mm Hg)	61 ± 11	74 ± 13	<0.0001
Cardiac index (L/min/m²)	2.6 ± 0.5	3.3 ± 1.0	<0.01
Respiratory pulse pressure variation (%)	10 ± 6	7 ± 3	<0.02
Arterial lactate (mmol/L)	2.8 ± 2.2	2.7 ± 2.3	0.29
Central venous oxygen saturation (%)	72 ± 7	74 ± 9	0.21
Central venous arterial PCO₂ (mm Hg)	6 ± 2	5 ± 2	<0.05
Central-peripheral temperature (°C)	5.0 ± 1.9	5.1 ± 2.2	0.78
Sublingual microcirculation
Total vascular density (mm/mm²)	16.4 ± 1.8	16.8 ± 1.0	0.19
Perfused vascular density (mm/mm²)	15.2 ± 2.9	16.1 ± 1.2	0.08
Proportion of perfused vessels	0.92 ± 0.14	0.96 ± 0.05	0.23
Microvascular flow index	2.6 ± 0.5	2.8 ± 0.2	0.12
Red blood cell velocity (μm/s)	912 ± 270	1,064 ± 200	<0.002
Heterogeneity flow index	1.2 ± 0.6	1.0 ± 0.2	0.09
CV red blood cell velocity	0.49 ± 0.24	0.40 ± 0.15	<0.03
Intestinal microcirculation
Total vascular density (mm/mm²)	16.9 ± 1.8	17.4 ± 1.9	0.22
Perfused vascular density (mm/mm²)	12.3 ± 6.7	13.0 ± 6.7	0.25
Proportion of perfused vessels	0.73 ± 0.39	0.73 ± 0.37	0.88
Microvascular flow index	2.0 ± 1.1	2.1 ± 1.1	0.34
Red blood cell velocity (μm/s)	679 ± 379	747 ± 419	0.12
Heterogeneity flow index	8.9 ± 18.0	15.4 ± 42.7	0.28
CV red blood cell velocity	0.46 ± 0.36	0.37 ± 0.26	0.31