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Table 2 Vancomycin treatment and vancomycin serum level

From: Vancomycin continuous infusion versus intermittent infusion during continuous venovenous hemofiltration: slow and steady may win the race

 

Vancomycin CI (n= 14)

Vancomycin II (n= 45)

p

Duration of therapy (day)

6.57 (3.25)

7.31 (3.34)

0.470

Loading dose (mg)

2232.14 (385.61)

1533.33 (565.58)

<0.001

Loading dose (mg/kg)

26.65 (3.06)

17.58 (5.72)

<0.001

Daily maintenance dose (mg/kg)

15.66 (6.26)

17.28 (4.96)

0.339

Maintenance dose - day 1 (mg)

1329.85 (335.61)

1328.6 (1286.47)

0.381

Maintenance dose - day 2 (mg)

1339.28 (348.17)

1585.68 (538.83)

0.116

Maintenance dose - day 3 (mg)

1428.57 (301.09)

1558.17 (495.61)

0.374

Total dose prior to first 24-hour level (mg)

3625 (497.5)

2000 (310.1)

<0.001

24-hour level (mcg/ml)

20.35 (2.78)

9.7 (3.52)

<0.001

48-hour level (mcg/ml)

20.8 (2.66)

15.61 (4.64)

0.001

72-hour level (mcg/ml)

19.25 (2.01)

17.74 (3.02)

0.201

24-hour level 15 mcg/ml to 25 mcg/ml, n (%)

14 (100)

2 (4.4)

<0.001

Time to therapeutic level (hr)

24 (0.56)

59.6 (21.6)

<0.001

Determination of serum concentration per day of vancomycin therapy, n

0.45 (0.24)

0.56 (0.21)

0.264

Determination of serum concentration, total per patient, n

2.62 (0.74)

3.26 (1.03)

0.136

  1. For CI group, maintenance dose starts immediately after loading.
  2. Value expressed as means (standard deviation).