Vancomycin CI (n= 14) | Vancomycin II (n= 45) | p | |
---|---|---|---|
Duration of therapy (day) | 6.57 (3.25) | 7.31 (3.34) | 0.470 |
Loading dose (mg) | 2232.14 (385.61) | 1533.33 (565.58) | <0.001 |
Loading dose (mg/kg) | 26.65 (3.06) | 17.58 (5.72) | <0.001 |
Daily maintenance dose (mg/kg) | 15.66 (6.26) | 17.28 (4.96) | 0.339 |
Maintenance dose - day 1 (mg) | 1329.85 (335.61) | 1328.6 (1286.47) | 0.381 |
Maintenance dose - day 2 (mg) | 1339.28 (348.17) | 1585.68 (538.83) | 0.116 |
Maintenance dose - day 3 (mg) | 1428.57 (301.09) | 1558.17 (495.61) | 0.374 |
Total dose prior to first 24-hour level (mg) | 3625 (497.5) | 2000 (310.1) | <0.001 |
24-hour level (mcg/ml) | 20.35 (2.78) | 9.7 (3.52) | <0.001 |
48-hour level (mcg/ml) | 20.8 (2.66) | 15.61 (4.64) | 0.001 |
72-hour level (mcg/ml) | 19.25 (2.01) | 17.74 (3.02) | 0.201 |
24-hour level 15 mcg/ml to 25 mcg/ml, n (%) | 14 (100) | 2 (4.4) | <0.001 |
Time to therapeutic level (hr) | 24 (0.56) | 59.6 (21.6) | <0.001 |
Determination of serum concentration per day of vancomycin therapy, n | 0.45 (0.24) | 0.56 (0.21) | 0.264 |
Determination of serum concentration, total per patient, n | 2.62 (0.74) | 3.26 (1.03) | 0.136 |