Table 3 Vancomycin treatment and serum level for loading dose > 20 mg/kg
Vancomycin CI (n= 14) | Vancomycin II (n= 13) | p | |
|---|---|---|---|
Loading dose (mg) | 2232.14 (385.61) | 1846.15 (665.66) | 0.074 |
Loading dose (mg/kg) | 26.65 (3.06) | 24.44 (2.86) | 0.082 |
Total dose prior to first 24-hour level (mg) | 3625 (497.5) | 1846.15 (665.66) | <0.001 |
Total dose prior to first 24-hour level (mg/kg) | 43.01 (8.31) | 24.1 (2.57) | <0.001 |
Maintenance dose - day 1 (mg) | 1329.85 (335.61) | 1623.07 (177.05) | 0.231 |
Maintenance dose - day 2 (mg) | 1339.28 (348.17) | 1455 (454.54) | 0.456 |
Maintenance dose - day 3 (mg) | 1428.57 (301.09) | 1496.6 (377.98) | 0.628 |
24-hour level (mcg/ml) | 20.35 (2.78) | 11.8 (2.7) | <0.001 |
24-hour level 15 mcg/ml to 25 mcg/ml, n (%) | 14 (100) | 1 (7%) | <0.001 |
Time to therapeutic level (hr) | 24 (0.56) | 48.9 (17.6) | < 0.001 |