Table 2 Comparisons between groups defined by pre-hospital statin use

Number of patients

92

253

1,302

Mean age (years)

67 ± 15

69 ± 13

p = 0.365^a

61 ± 17

p = 0.001 ^a

Gender (male/female)

40/52

130/123

p = 0.194^b

700/602

p = 0.056^b

Mean temperature, time 0 (°C)

37.3 ± 1.5

37.2 ± 1.6

p = 0.766^a

37.1 ± 1.5

p = 0.436^a

Mean heart rate, time 0, (beats per min)

106 ± 22

107 ± 25

p = 0.860^a

112 ± 25

p = 0.033a

Mean respiratory rate, time 0 (breaths per min)

24 ± 8

24 ± 9

p = 0.512^a

25 ± 9

p = 0.351^a

Mean arterial pressure, time 0 (mmHg)

76 ± 22

75 ± 22

p = 0.797^a

76 ± 22

p = 0.974^a

Mean arterial pH, time 0

7.34 ± 0.13

7.36 ± 0.12

p = 0.169^a

7.35 ± 0.13

p = 0.577^a

Mean creatinine, time 0 (mg/dL)

3.5 ± 3.0

3.1 ± 2.6

p = 0.357^c

2.7 ± 2.9

p = 0.003 ^c

Mean leukocyte count, time 0 (K/μL)

14.7 ± 9.3

16.5 ± 12.7

p = 0.225^a

16.1 ± 17.0

p = 0.459^a

Mean hematocrit, time 0 (%)

32.6 ± 6.8

32.3 ± 6.5

p = 0.688^a

32.9 ± 15.1

p = 0.860^a

Mean platelet count, time 0 (K/μL)

242 ± 124

238 ± 130

p = 0.813^a

230 ± 143

p = 0.431^a

Mean bilirubin, time 0 (mg/dL)

1.2 ± 1.8

1.1 ± 2.1

p = 0.755^a

1.6 ± 3.1

p = 0.221^a

Mean lactate (mmol/L)

3.2 ± 2.8

3.6 ± 3.2

p = 0.454^c

4.0 ± 3.4

p = 0.011 ^c

Mean APACHE II, time 0

18.8 ± 6.5

19.4 ± 7.1

p = 0.484^a

18.6 ± 7.4

p = 0.833^a

Time to antibiotics (min)

190 ± 152

166 ± 155

p = 0.300^a

195 ± 226

p = 0.862^a

Mean fluid volume administered, first 24 h (L)

4.542 ± 3.166

5.402 ± 3.348

p = 0.036 ^a

4.955 ± 4.477

p = 0.393^a

Mean first CVP value (cm H₂O)

12 ± 6

11 ± 6

p = 0.361^a

10 ± 6

p = 0.123^a

Median glucose, first 24 h (mg/dL)

142 ± 82

143 ± 56

p = 0.962^a

134 ± 67

p = 0.226^a

Mixed venous oxygen saturation (%)

71 ± 12

70 ± 15

p = 0.737^a

70 ± 16

p = 0.753^a

Use of vasopressors, number (%)

41 (44.6%)

115 (45.5%)

p = 0.883^b

576 (44.2%)

p = 0.952^b

Intubation, first 24 h, number (%)

37 (40.2%)

118 (46.6%)

p = 0.289^b

641 (49.2%)

p = 0.095^b

Dialysis, number (%)

7 (7.6%)

24 (9.5%)

p = 0.590^b

48 (3.7%)

p = 0.062^b

Abdominal source, number (%)

13 (14.1%)

29 (11.5%)

p = 0.503^b

172 (13.2%)

p = 0.823^b

Lung source (%)

27 (29.3%)

83 (32.8%)

p = 0.542^b

396 (30.4%)

p = 0.314^b

Urologic source (%)

16 (17.4%)

52 (20.6%)

p = 0.514^b

192 (14.7%)

p = 0.872^b

History of neoplasia (%)

16 (17.4%)

67 (26.5%)

p = 0.081^b

334 (25.7%)

p = 0.077^b

History of cardiac disease (%)

72 (78.3%)

196 (77.4%)

p = 0.876^b

690 (53.0%)

p < 0.0001 ^b

History of chronic kidney disease (%)

51 (55.4%)

131 (51.8%)

p = 0.547^b

410 (31.5%)

p < 0.0001 ^b

History of liver disease (%)

9 (9.8%)

20 (7.9%)

p = 0.578^b

252 (19.4%)

p = 0.023 ^b

Mortality (%)

17 (18.5%)

76 (30.0%)

p = 0.032 ^b

396 (30.4%)

p = 0.015 ^b