|
Total SOFA score median (IQR)
|
5 (3–9)
|
9 (5–13)
|
<0.01
|
|
Total SOFA score ≥ 8
|
122 (35.5)
|
260 (60.0)
|
<0.01
|
|
Total SOFA score ≥ 5
|
198 (57.6)
|
367 (84.8)
|
<0.01
|
|
Total SOFA score ≥ 3
|
282 (82.0)
|
418 (96.5)
|
<0.01
|
|
Respiratory failure
|
119 (34.6)
|
182 (42.0)
|
0.03
|
|
Neurologic failure
|
104 (30.2)
|
281 (64.9)
|
<0.01
|
|
Circulatory failure
|
103 (29.9)
|
192 (44.3)
|
<0.01
|
|
Hepatic failure
|
10 (2.9)
|
37 (8.5)
|
<0.01
|
|
Hematologic failure
|
14 (4.1)
|
54 (12.5)
|
<0.01
|
|
Renal failure
|
56 (16.3)
|
118 (27.3)
|
<0.01
|
|
Treatments already engaged:
|
|
Endotracheal ventilation
|
213 (61.9)
|
375 (86.6)
|
<0.01
|
|
Non-invasive ventilation
|
50 (27.9)
|
35 (17.3)
|
<0.01
|
|
Inotrope use
|
107 (31.1)
|
206 (47.6)
|
<0.01
|
|
Renal replacement therapy
|
24 (7.2)
|
100 (23.6)
|
<0.01
|
|
Antibiotics
|
158 (45.9)
|
256 (59.1)
|
<0.01
|
|
Blood product transfusion
|
46 (14.9)
|
77 (18.6)
|
0.11
|
|
Surgery needed
|
22 (6.4)
|
47 (10.9)
|
0.02
|
|
Rationales to justify WhWd:
|
|
No additional information needed
|
246 (78.1)
|
356 (90.8)
|
<0.01
|
|
Limited subsequent autonomy
|
252 (80.3)
|
329 (81.4)
|
0.34
|
|
Absence of curative therapy
|
199 (61.4)
|
360 (86.5)
|
<0.01
|
|
Non-responsive to treatment
|
180 (56.6)
|
336 (83.6)
|
<0.01
|
|
End-stage incurable severe disease
|
185 (58.4)
|
289 (73.5)
|
<0.01
|
|
Limited subsequent relational QOL
|
177 (57.7)
|
265 (68.3)
|
<0.01
|
|
Limited autonomy before admission
|
184 (55.9)
|
133 (33.8)
|
<0.01
|
|
Very advanced age
|
101 (31.9)
|
109 (27.9)
|
0.14
|
|
Excessive treatment felt by relatives
|
59 (18.9)
|
113 (28.2)
|
<0.01
|
|
Patient’s wish to limit treatment
|
59 (19.1)
|
51 (13.1)
|
0.02
|
|
Awareness of patient’s preferences
|
86 (25.0)
|
95 (21.9)
|
0.31
|
|
External consultant physician
|
142 (41.3)
|
214 (49.4)
|
0.02
|
