Variables | All patients | Alive | Early deaths | Late deaths | p |
---|---|---|---|---|---|
n = 543 | n = 299 | n = 78 | n = 166 | ||
Demographics | |||||
Age, years | 66 ± 15 | 63 ± 16 | 70 ± 15 | 69 ± 13 | <0.0001 |
Male gender | 346 (64) | 196 (66) | 49 (63) | 101 (61) | 0.64 |
Comorbidities | |||||
Malignancy | 139 (25) | 61 (20) | 32 (41) | 46 (28) | 0.0008 |
Chronic heart failure | 126 (23) | 59 (20) | 18 (23) | 49 (29) | 0.06 |
Chronic pulmonary disease | 103 (19) | 47 (16) | 15 (19) | 41 (25) | 0.06 |
Diabetes mellitus | 96 (18) | 46 (15) | 22 (28) | 28 (17) | 0.03 |
Cirrhosis | 65 (12) | 28 (9) | 9 (11) | 28 (17) | 0.06 |
Chronic kidney failure | 60 (11) | 29 (10) | 8 (10) | 23 (14) | 0.38 |
Factors of immunosuppression | |||||
Chemotherapy during the last 3 months | 64 (12) | 33 (11) | 13 (17) | 18 (11) | 0.36 |
Leuconeutropenia | 41 (7) | 21 (7) | 13 (17) | 7 (4) | 0.002 |
Corticosteroid treatment | 91 (17) | 39 (13) | 15 (19) | 37 (22) | 0.03 |
Other immunosuppressive drugs | 46 (8) | 19 (6) | 8 (10) | 19 (11) | 0.14 |
HIV infection | 6 (1) | 4 (1) | 0 (0) | 2 (1) | 0.86 |
Infection characteristics | |||||
Healthcare-related infections | 286 (53) | 148 (49) | 44 (56) | 94 (57) | 0.26 |
Source of infection | 0.003 | ||||
Lung | 286 (53) | 146 (49) | 43 (55) | 97 (58) | |
Abdominal | 91 (17) | 40 (14) | 15 (19) | 36 (22) | |
Urinary tract | 63 (12) | 46 (15) | 6 (8) | 11 (7) | |
Catheter | 18 (3) | 15 (5) | 1 (1) | 2 (1) | |
Skin and soft tissue | 33 (6) | 22 (7) | 2 (3) | 9 (5) | |
Othersa | 52 (9) | 30 (10) | 11 (14) | 11 (7) | |
Microbiological documentation | 376 (69) | 221 (74) | 48 (61) | 107 (64) | 0.03 |
Type of microorganismb | 0.50 | ||||
Gram-negative bacteria | 206 (55) | 127 (58) | 26 (54) | 53 (49) | |
Gram-positive bacteria | 151 (40) | 82 (37) | 21 (44) | 48 (44) | |
Othersc | 19 (5) | 11 (5) | 1 (2) | 7 (6) | |
Positive blood cultures | 166 (30) | 102 (34) | 22 (28) | 42 (25) | 0.12 |
Admission biological findings | |||||
Leucocytes (G/L) | 12.0 [5.6–18.7] | 11.3 [6–18.4] | 9.2 [1.7–25] | 13 [6.7–18] | 0.07 |
Arterial blood lactate (mmol/L) | 2.9 [1.5–5.4] | 2.2 [1.4–4] | 7.8 [4.3–11.8] | 2.7 [1.4–5.9] | <0.0001 |
Creatininemia (μmol/L) | 139 [88–215] | 129 [82–186] | 196 [127–281] | 137 [85–214] | 0.02 |
Prognostic scoring systems | |||||
Admission SOFA score | 9 [6–12] | 9 [5–12] | 11 [9–14] | 9 [5–12] | 0.0005 |
Admission SAPS II | 66 [51–85] | 58 [46–80] | 86 [77–101] | 67 [53–83] | <0.0001 |
Organ failure supports | |||||
Mechanical ventilation | 476 (88) | 241 (81) | 77 (99) | 158 (95) | <0.0001 |
Renal replacement therapy | 277 (51) | 101 (34) | 65 (83) | 111 (67) | <0.0001 |
Stress-dose corticosteroids | 250 (46) | 111 (37) | 58 (74) | 81 (49) | <0.0001 |