Right over left ventricular end-diastolic area relevance to predict hemodynamic intolerance of high-frequency oscillatory ventilation in patients with severe ARDS

Annals of Intensive Care

Table 2 Evolution of the hemodynamic characteristics during the study

	CMV_pre	HFOV connection	H_{1 HFOV}	H_{3 HFOV}
Concerned patients number	24	24	23	19
Heart rate (beats/min)	102 ± 22	102 ± 23	102 ± 23	102 ± 24
Systolic arterial pressure (mmHg)	120 ± 18	119 ± 23	119 ± 19	116 ± 17
Diastolic arterial pressure (mmHg)	62 ± 11	63 ± 12	65 ± 11	62 ± 11
Mean arterial pressure (mmHg)	81 ± 11	81 ± 13	80 ± 14	80 ± 12
Pulse pressure (mmHg)	57 ± 13	56 ± 17	54 ± 17	54 ± 13
Cardiac index (L min⁻¹ m⁻²) (TPTD)	3.7 ± 1.1^b,c,d	3.3 ± 1.3^a	3.3 ± 1.2^a	3.1 ± 1.1^a
SVI (mL min⁻¹ m⁻²) (TPTD)	36 ± 11^b,c,d	33 ± 14^a	33 ± 14^a	32 ± 14^a
GEDI (mL min⁻¹ m⁻²) (TPTD)	680 ± 140^b,c,d	634 ± 134^a	646 ± 126^a	625 ± 112^a
CFI (min⁻¹) (TPTD)	5.5 ± 1.8^b,c,d	5.2 ± 1.9^a	5.0 ± 1.8^a	5.0 ± 1.5^a
LVEF (%) (TTE)	53 ± 16^b,c,d	50 ± 17^a	49 ± 15^a	49 ± 13^a
RVEDA/LVEDA ratio (TTE)	0.61 ± 0.15^b,c,d	0.70 ± 0.18^a	0.72 ± 0.18^a	0.67 ± 0.14^a
RVEDA/LVEDA ratio >0.6 [n (%)]	11 (46)^b,c	17 (71)^a,d	17 (74)^a,d	10 (53)^b,c
ACP echocardiographic pattern [n (%)]	5 (21)^b,c	11 (46)^a,d	10 (43)^a,d	6 (32)^b,c
LVOT VTI (cm) (TTE)	17 ± 5^b,c,d	14 ± 5^a	14 ± 5^a	14 ± 5^a
E-wave (cm s⁻¹) (TTE)	90 ± 23^c	86 ± 20^c	80 ± 21^a,b,d	91 ± 22^c
A-wave (cm s⁻¹) (TTE)	57 ± 16	58 ± 12	54 ± 12	57 ± 15
E′ (cm s⁻¹) (TTE)	14 ± 5	14 ± 5	14 ± 4	15 ± 5
DTE (ms) (TTE)	207 ± 51	204 ± 44	213 ± 38	205 ± 46
E/A (TTE)	1.8 ± 0.5^b,c	1.6 ± 0.6^a	1.6 ± 0.5^a	1.8 ± 0.7^b,c
E/E′ (TTE)	8.3 ± 2.9	8.4 ± 2.9	7.4 ± 3.6	8.0 ± 3.0
Norepinephrine (μg kg⁻¹ min⁻¹)	0.59 ± 0.78	0.59 ± 0.78	0.58 ± 0.78	0.53 ± 0.69

Results are given as mean ± SD
CMV conventional mechanical ventilation, HFOV high frequency oscillation ventilation, TPTD transpulmonary thermodilution, SVI stroke volume index, GEDI global end diastolic index, CFI cardiac function index, LVEF left ventricular ejection fraction, TTE transthoracic echocardiography, LVEDA left ventricular end diastolic area, RVEDA right ventricular end diastolic area, LVOT VTI velocity–time integral in the left ventricular outflow tract, DTE E-wave deceleration time
^a p < 0.05 for all data as compared to CMVpre
^b p < 0.05 for all data as compared to HFOV Connection
^c p < 0.05 for all data as compared to H₁ _HFOV
^d p < 0.05 for all data as compared to H₃ _HFOV