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Table 2 Evolution of the hemodynamic characteristics during the study

From: Right over left ventricular end-diastolic area relevance to predict hemodynamic intolerance of high-frequency oscillatory ventilation in patients with severe ARDS

 

CMVpre

HFOV connection

H1 HFOV

H3 HFOV

Concerned patients number

24

24

23

19

Heart rate (beats/min)

102 ± 22

102 ± 23

102 ± 23

102 ± 24

Systolic arterial pressure (mmHg)

120 ± 18

119 ± 23

119 ± 19

116 ± 17

Diastolic arterial pressure (mmHg)

62 ± 11

63 ± 12

65 ± 11

62 ± 11

Mean arterial pressure (mmHg)

81 ± 11

81 ± 13

80 ± 14

80 ± 12

Pulse pressure (mmHg)

57 ± 13

56 ± 17

54 ± 17

54 ± 13

Cardiac index (L min−1 m−2) (TPTD)

3.7 ± 1.1b,c,d

3.3 ± 1.3a

3.3 ± 1.2a

3.1 ± 1.1a

SVI (mL min−1 m−2) (TPTD)

36 ± 11b,c,d

33 ± 14a

33 ± 14a

32 ± 14a

GEDI (mL min−1 m−2) (TPTD)

680 ± 140b,c,d

634 ± 134a

646 ± 126a

625 ± 112a

CFI (min−1) (TPTD)

5.5 ± 1.8b,c,d

5.2 ± 1.9a

5.0 ± 1.8a

5.0 ± 1.5a

LVEF (%) (TTE)

53 ± 16b,c,d

50 ± 17a

49 ± 15a

49 ± 13a

RVEDA/LVEDA ratio (TTE)

0.61 ± 0.15b,c,d

0.70 ± 0.18a

0.72 ± 0.18a

0.67 ± 0.14a

RVEDA/LVEDA ratio >0.6 [n (%)]

11 (46)b,c

17 (71)a,d

17 (74)a,d

10 (53)b,c

ACP echocardiographic pattern [n (%)]

5 (21)b,c

11 (46)a,d

10 (43)a,d

6 (32)b,c

LVOT VTI (cm) (TTE)

17 ± 5b,c,d

14 ± 5a

14 ± 5a

14 ± 5a

E-wave (cm s−1) (TTE)

90 ± 23c

86 ± 20c

80 ± 21a,b,d

91 ± 22c

A-wave (cm s−1) (TTE)

57 ± 16

58 ± 12

54 ± 12

57 ± 15

E′ (cm s−1) (TTE)

14 ± 5

14 ± 5

14 ± 4

15 ± 5

DTE (ms) (TTE)

207 ± 51

204 ± 44

213 ± 38

205 ± 46

E/A (TTE)

1.8 ± 0.5b,c

1.6 ± 0.6a

1.6 ± 0.5a

1.8 ± 0.7b,c

E/E′ (TTE)

8.3 ± 2.9

8.4 ± 2.9

7.4 ± 3.6

8.0 ± 3.0

Norepinephrine (μg kg−1 min−1)

0.59 ± 0.78

0.59 ± 0.78

0.58 ± 0.78

0.53 ± 0.69

  1. Results are given as mean ± SD
  2. CMV conventional mechanical ventilation, HFOV high frequency oscillation ventilation, TPTD transpulmonary thermodilution, SVI stroke volume index, GEDI global end diastolic index, CFI cardiac function index, LVEF left ventricular ejection fraction, TTE transthoracic echocardiography, LVEDA left ventricular end diastolic area, RVEDA right ventricular end diastolic area, LVOT VTI velocity–time integral in the left ventricular outflow tract, DTE E-wave deceleration time
  3. a p < 0.05 for all data as compared to CMVpre
  4. b p < 0.05 for all data as compared to HFOV Connection
  5. c p < 0.05 for all data as compared to H1 HFOV
  6. d p < 0.05 for all data as compared to H3 HFOV